420831-40-9 Usage
Uses
Used in Pharmaceutical Industry:
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide is used as a selective SIRT2 inhibitor for its potential therapeutic applications in treating metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases. Its ability to inhibit SIRT2 makes it a promising candidate for drug development in these areas.
Used in Neurodegenerative Disease Research:
In the field of neurodegenerative disease research, 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide is used as a tool to study the role of SIRT2 in diseases such as Alzheimer's, Huntington's, and Parkinson's. By inhibiting SIRT2, researchers can gain insights into the underlying mechanisms and potential therapeutic targets for these conditions.
Used in Neuroprotection:
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide is used as a neuroprotective agent in culture, where it has been shown to diminish neuronal cell death induced by mutant huntingtin fragment. This suggests its potential use in the development of treatments for neurodegenerative diseases associated with protein misfolding and aggregation.
Used in Cholesterol Regulation:
In the field of cholesterol regulation, 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide is used as a compound that down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo. This indicates its potential application in the development of therapies for managing cholesterol-related conditions and their associated health risks.
References
1) Tylor et al. (2011), A brain-permeable small molecule that reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase; ACS Chem. Biol., 6 540
2) Chopra et al. (2012), The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington’s disease mouse models; Cell Rep., 2 1492
Check Digit Verification of cas no
The CAS Registry Mumber 420831-40-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,0,8,3 and 1 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 420831-40:
(8*4)+(7*2)+(6*0)+(5*8)+(4*3)+(3*1)+(2*4)+(1*0)=109
109 % 10 = 9
So 420831-40-9 is a valid CAS Registry Number.
420831-40-9Relevant academic research and scientific papers
A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues
Verlee, Arno,Heugebaert, Thomas,Van Der Meer, Tom,Kerchev, Pavel I.,Van Breusegem, Frank,Stevens, Christian V.
, p. 303 - 312 (2017/03/14)
For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are known for their bioactivity, a chemoselective procedure has been developed starting from m-(chlorosulfonyl)benzoyl chloride. Although a chemoselective process in batch was already reported, a continuous-flow process reveals an increased selectivity at higher temperatures and without catalysts. In total, 15 analogues were synthesized, using similar conditions, with yields ranging between 65 and 99%. This is the first automated and chemoselective synthesis of m-sulfamoylbenzamide analogues.
