420846-52-2Relevant articles and documents
The facile construction of the phthalazin-1(2H)-one scaffold via copper-mediated C-H(sp2)/C-H(sp) coupling under mild conditions
Zhu, Wei,Wang, Bao,Zhou, Shengbin,Liu, Hong
, p. 1624 - 1631 (2016/04/10)
A novel strategy for the construction of the phthalazin-1(2H)-one scaffold has been developed by means of a copper-mediated cascade C-H/C-H coupling and intramolecular annulations and a subsequent facile hydrazinolysis. This C-H activation transformation proceeds smoothly with wide generality, good functional tolerance and high stereo- And regioselectivity under mild conditions. Through the removal of the directing group, the resulting moiety could easily be transformed into the phthalazin-1(2H)-one scaffold, which is known to be a privileged moiety and a bioactive nucleus in pharmaceuticals.
Tuning selectivity of anionic cyclizations: Competition between 5-exo and 6-endo-dig closures of hydrazides of o-acetylenyl benzoic acids and based-catalyzed fragmentation/recyclization of the initial 5-exo-dig products
Vasilevsky, Sergey F.,Mikhailovskaya, Tat'yana F.,Mamatyuk, Victor I.,Salnikov, Georgy E.,Bogdanchikov, Georgy A.,Manoharan, Mariappan,Alabugin, Igor V.
supporting information; experimental part, p. 8106 - 8117 (2010/03/04)
(Chemical Equation Presented) Depending on the reaction conditions and the nature of substituents at the triple bond, anionic cyclizations of hydrazides of o-acetylenyl benzoic acids can be selectively directed along three alternative paths, each of which
