42086-72-6Relevant academic research and scientific papers
Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds
Olmo, Esther Del,Barboza, Bianca,Chiaradia, Louise D.,Moreno, Alicia,Carrero-Lérida, Juana,González-Pacanowska, Dolores,Mu?oz, Victoria,López-Pérez, José L.,Giménez, Alberto,Benito, Agustín,Martínez, Antonio R.,Ruiz-Pérez, Luis M.,San Feliciano, Arturo
experimental part, p. 5379 - 5386 (2011/12/14)
The synthesis of several series of imidazo[2,1-a]isoindol-5-ol derivatives and the results of their evaluation against Plasmodium falciparum are presented and discussed. The effects of electron-withdrawing or-donating substituents on different parts of the molecule, as well as those produced by the incorporation of an additional fused ring, were analyzed. Several compounds showed significant antimalarial activity in vitro with IC50 values as low as 60 nM and a certain efficacy in vivo by reducing parasitemia in Plasmodium berghei mouse models.
Anti-HIV activity of stilbene-related heterocyclic compounds
Bedoya, Luis M.,del Olmo, Esther,Sancho, Rocio,Barboza, Bianca,Beltran, Manuela,Garcia-Cadenas, Ana E.,Sanchez-Palomino, Sonsoles,Lopez-Perez, Jose L.,Munoz, Eduardo,Feliciano, Arturo San,Alcami, Jose
, p. 4075 - 4079 (2007/10/03)
Viral transcription has not been routinely targeted in the development of new antiviral drugs. This crucial step of the viral cycle depends on the concerted action of cellular and viral proteins such as NF-κB and Tat. In the present study, stilbene-related heterocyclic compounds including benzalphthalide, phthalazinone, imidazoindole and pyrimidoisoindole derivatives are tested for their anti-HIV activity. Original assays based on recombinant viruses were used to evaluate HIV replication inhibition and stably transfected cell lines were used to evaluate inhibition of Tat and NF-κB proteins. Some of the stilbene-related heterocyclic compounds analysed displayed anti-HIV activity through interference with NF-κB and Tat function. Moreover, compounds inhibiting both targets displayed a stronger activity on viral replication.
Vasorelaxant activity of phthalazinones and related compounds
Olmo, Esther del,Barboza, Bianca,Ybarra, Ma Ines,Lopez-Perez, Jose Luis,Carron, Rosalia,Sevilla, Ma Angeles,Boselli, Cinthia,Feliciano, Arturo San
, p. 2786 - 2790 (2007/10/03)
Several series of dihydrostilbenamide, imidazo[2,1-a]isoindole, pyrimido[2,1-a]isoindole and phthalazinone derivatives were obtained and their vasorelaxant activity was measured on isolated rat aorta rings pre-contracted with phenylephrine (10-5 M). Some phthalazinones attained, practically, the total relaxation of the organ at micromolar concentrations. For the most potent compound 9h (EC50 = 0.43 μM) the affinities for α1A, α1B and α1D adrenergic sub-receptors were determined.
