4209-25-0

Basic information

• Product Name: Ethanone, 2-chloro-1-(2-chlorophenyl)-
• CAS NO: 4209-25-0
• Molecular Formula: C8H6Cl2O
• Molecular Weight: 189.041
• Mol File: 4209-25-0.mol

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-chloro-1-(2-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-chloro-1-(2-chlorophenyl)-(4209-25-0)
• EPA Substance Registry System: Ethanone, 2-chloro-1-(2-chlorophenyl)-(4209-25-0)

Safety Data

• Hazardous Substances Data: 4209-25-0(Hazardous Substances Data)

Usage

Uses

Used in Law Enforcement and Riot Control:
Ethanone, 2-chloro-1-(2-chlorophenyl)is used as a tear gas for crowd control and riot management. Its strong irritating effects on the eyes, skin, and respiratory system make it an effective tool for dispersing crowds and maintaining public order.
Used in Chemical Synthesis:
Ethanone, 2-chloro-1-(2-chlorophenyl)is used as a chemical intermediate in the production of various pesticides and pharmaceuticals. Its unique chemical structure allows it to be a versatile building block for the synthesis of a wide range of compounds.
Used in Research and Development:
Ethanone, 2-chloro-1-(2-chlorophenyl)is used in research and development for studying its chemical properties and potential applications in various fields. Its reactivity and stability make it an interesting subject for scientific investigation and innovation.

Upstream product

• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 54143-03-2 1-chloro-2-(chloroethynyl)benzene 
• 2039-87-4 2-chlorostyrene 
• 67-56-1 methanol 
• 10291-39-1 2,2,2-trichloro-1-(2-chloro-phenyl)-ethanol 

Downstream Products

• 49851-53-8 6-chloro-2-(2-chloro-phenyl)-3H-pyrido[2,3-b][1,4]thiazine 
• 102061-18-7 1,4-bis(2-chlorophenyl)butane-1,4-dione 
• 130-03-0 thioindoxyl 
• 62717-50-4 (R)-(-)-2-(2-chlorophenyl)oxirane 
• 29261-25-4 (-)-Isoprophenamine 

Relevant articles and documents

Unmasking the Hidden Carbonyl Group Using Gold(I) Catalysts and Alcohol Dehydrogenases: Design of a Thermodynamically-Driven Cascade toward Optically Active Halohydrins

A concurrent cascade combining the use of a gold(I) N-heterocyclic carbene (NHC) and an alcohol dehydrogenase (ADH) is disclosed for the synthesis of highly valuable enantiopure halohydrins in an aqueous medium and under mild reaction conditions. The meth

Facile Synthesis of α-Haloketones by Aerobic Oxidation of Olefins Using KX as Nonhazardous Halogen Source

An operationally simple and safe synthesis of α-haloketones using KBr and KCl as nonhazardous halogen sources is reported. It involves an iron-catalysed reaction of alkenes with KBr/KCl using O2 as terminal oxidant under the irradiation of visible-light. This strategy avoids the risks associated with handling halo-contained electrophiles (Cl2, Br2, NCS, NBS). The process is tolerant to several functional groups, and extended to a range of substituted styrenes in up to 89% yield. A radical reaction pathway is proposed based on control experiments and spectroscopy studies.

CV-driven Optimization: Cobalt-Catalyzed Electrochemical Expedient Oxychlorination of Alkenes via ORR

Instead of screening reaction conditions by yield-based chemical trial-and-error, potential-based cyclic voltammetry was alternatively employed for optimization of electrochemical oxychlorination of alkenes. With this unconventional screening method, the catalyst system including catalysts, molar ratio of chloride sources and solvents were identified in a rational, time- and energy-efficient manner. The optimal catalytic system in combination with oxygen reduction reaction enabled broad substrate scopes for the desired transformation by taking advantages of persistent radical effect. UV-vis and CV titration experiments confirmed the in-situ formed catalytic species [CoCl5]. Moreover, cyclic voltammetry was applied to obtain mechanistic insights in our reaction system. (Figure presented.).

The Mn-catalyzed paired electrochemical facile oxychlorination of styrenes: Via the oxygen reduction reaction

Reported herein is the electrochemical engendering of chlorine radicals by a manganese catalyst with a controllable pattern, and inexpensive MgCl2 as the chlorine source. In combination with the oxygen reduction reaction, chloroacetophenones were synthesized with abundant styrene as the feedstock in good to excellent yields.

Iridium-Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins

Iridium-catalyzed asymmetric hydrogenation of prochiral halogenated ketones was successfully developed to prepare various chiral halohydrins with high reactivities and excellent enantioselectivities under basic reaction condition (up to >99% conversion, 99% yield, >99% ee). Moreover, gram-scale experiment was performed well in the presence of just 0.005 mol% (S/C=20 000) Ir/f-amphox catalyst with 99% yield and >99% ee. (Figure presented.).

Cascade Trisulfur Radical Anion (S3?-) Addition/Electron Detosylation Process for the Synthesis of 1,2,3-Thiadiazoles and Isothiazoles

Trisulfur radical anion (S3?-) mediated reactions with in situ formed azoalkenes and α,β-usaturated N-sulfonylimines for the construction of 1,2,3-thiadiazoles and isothiazoles has been developed. S3?- is in situ generated from potassium sulfide in DMF. These two approaches provide a new, safe, and simple way to construct 4-subsituted 1,2,3-thiadiazoles, 5-subsituted 1,2,3-thiadiazoles, and isothiazole in good yields. The reactions include the formation of the new C-S and N-S bonds via S3?- addition and electron detosylation under mild conditions.

Mild and efficient α-chlorination of carbonyl compounds using ammonium chloride and oxone (2KHSO5·KHSO4· K2SO4)

A simple protocol for the α-monochlorination of ketones and 1,3-dicarbonyl compounds utilizing NH4Cl as a source of chlorine and Oxone as an oxidant in methanol without catalyst is presented. The reaction proceeds at ambient temperature in yields ranging from moderate to excellent.

Copper(I)-promoted synthesis of chloromethyl ketones from trichloromethyl carbinols

(Chemical Equation Presented) Reaction of several trichloromethyl carbinols with 2 equiv of CuCl/bpy in refluxing DCE for 3 h afforded chloromethyl ketones in excellent yield by 1,2-H shift in the copper-chlorocarbenoid intermediate.

Synthesis of cyclic thioethers through tandem C(sp3)-S and C(sp2)-S bond formations from α,β′-dichloro vinyl ketones

(Chemical Equation Presented) The synthesis of 5- to 8-memebered cyclic thioethers 4 has been achieved through a simple two-step sequence. The present methodology utilizes the facile Friedel-Crafts acylation of terminal alkynes 1 with acid chlorides 2 fol

Pyridazine derivatives having a psychotropic action and compositions

This invention relates to pyridazine derivatives substituted in the 4-position by a cyano group having psychotropic activity. It also relates to a process for the preparation of these products and their application as medicaments. STR1