42098-25-9

Basic information

• Product Name: 5-chloro-1-Methyl-4-nitro-1H-pyrazole
• Synonyms: 5-chloro-1-Methyl-4-nitro-1H-pyrazole;5-Chloro-1-methyl-4-nitropyrazole;1H-Pyrazole, 5-chloro-1-Methyl-4-nitro-
• CAS NO: 42098-25-9
• Molecular Formula: C₄H₄ClN₃O₂
• Molecular Weight: 161.54646
• Mol File: 42098-25-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 135-137℃
• Boiling Point: 273℃
• Flash Point: 119℃
• Appearance: /
• Density: 1.65
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.31±0.10(Predicted)
• CAS DataBase Reference: 5-chloro-1-Methyl-4-nitro-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-1-Methyl-4-nitro-1H-pyrazole(42098-25-9)
• EPA Substance Registry System: 5-chloro-1-Methyl-4-nitro-1H-pyrazole(42098-25-9)

Safety Data

• Hazardous Substances Data: 42098-25-9(Hazardous Substances Data)

Usage

General Description

5-chloro-1-Methyl-4-nitro-1H-pyrazole is a chemical compound belonging to the pyrazole group, known for their significant role in medicinal chemistry. It bears a versatile core structure that serves as a basis for an extremely wide range of bioactive compounds. Incorporated with chloro, methyl, and nitro substituents, this compound exhibits unique attributes that can influence its physicochemical properties and biological activities. Its complicated structure suggests that it may be used in the synthesis of pharmaceuticals and agrochemicals. Specific details, such as its physical and chemical properties, toxicity, or biological activity, may depend on the context and are often explored in specific scientific research or industrial applications.

InChI:InChI=1S/C4H4ClN3O2/c1-7-4(5)3(2-6-7)8(9)10/h2H,1H3

Upstream product

• 3994-50-1 1-methyl-4-nitropyrazole 
• 2075-46-9 4-nitro-1H-pyrazole 
• 67-72-1 hexachloroethane 

Downstream Products

• 1338718-97-0 C₁₅H₁₈N₄O₄ 
• 1428573-85-6 benzaldehyde O-6,6-difluoro-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepan-4-yloxime 
• 1338718-11-8 tert-butyl 3-(4-amino-1-methyl-1H-pyrazol-5-yl)phenylcarbamate 
• 1428573-74-3 3-fluoro-5-(4-methoxybenzyloxy)-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepane 

Relevant articles and documents

Synthesis and Biological Profiling of Pyrazolo-Fused 7-Deazapurine Nucleosides

A series of 8-substituted 1-methyl-1,4-dihydropyrazolo[3′,4′:4,5]pyrrolo[2,3-d]pyrimidine (methylpyrazolo-fused 7-deazapurine) ribonucleosides have been designed and synthesized. Two synthetic approaches to the key heterocyclic aglycon 7, (i) a six-step c

NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Compound of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, X, Y and G are as defined in the description, and their use in the manufacture of medicaments.

Kinase inhibitor, and preparation and application of kinase inhibitor

The invention provides a compound shown as a formula (I), or a stereoisomer, a tautomer, nitrogen oxide, metabolite, a prodrug, pharmaceutically acceptable salt or solvate of the compound, and application of the compound to preparing drugs or drug compositions for treating Pim kinase-mediated diseases.