421-52-3

Basic information

• Product Name: 2,2,2-trifluoroethanethioamide
• Synonyms: 2,2,2-Trifluorothioacetamide, tech.;EthanethioaMide, 2,2,2-trifluoro-;2,2,2-TrifluoroethanethioacetaMide;Trifluorothioacetamide
• CAS NO: 421-52-3
• Molecular Formula: C₂H₂F₃NS
• Molecular Weight: 129.1
• Mol File: 421-52-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 42-43 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 104°Cat760mmHg
• Flash Point: 16.7°C
• Appearance: /
• Density: 1.49
• Vapor Pressure: 31.5mmHg at 25°C
• Refractive Index: 1.434
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 11.02±0.29(Predicted)
• CAS DataBase Reference: 2,2,2-trifluoroethanethioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoroethanethioamide(421-52-3)
• EPA Substance Registry System: 2,2,2-trifluoroethanethioamide(421-52-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 421-52-3(Hazardous Substances Data)

Usage

General Description

2,2,2-trifluoroethanethioamide, also known as trifluoroethyl thioacetamide, is a chemical compound with the molecular formula C4H6F3NS. It is a thioamide derivative with three fluorine atoms attached to the carbon atom and a sulfur atom bonded to the nitrogen atom. 2,2,2-trifluoroethanethioamide is used in organic synthesis as a source of nucleophilic 2,2,2-trifluoroethylthio anion, which can participate in a variety of reactions. Additionally, it is also used as a building block for the synthesis of pharmaceuticals and agrochemicals. This chemical has a wide range of industrial applications due to its unique chemical properties and reactivity.

InChI:InChI=1/C2H2F3NS/c3-2(4,5)1(6)7/h(H2,6,7)

Upstream product

• 354-38-1 2,2,2-trifluoroacetamide 
• 19172-47-5 Lawessons reagent 
• 353-85-5 trifluoroacetonitrile 
• 7783-06-4 hydrogen sulfide 
• 785825-81-2 trifluoromethylhydrazine 

Downstream Products

• 177561-43-2 5-(4-fluorophenyl)-4-(4-methylthiophenyl)-2-trifluoromethylthiazole 
• 177561-23-8 4-(4-fluorophenyl)-5-(4-methylthiophenyl)-2-trifluoromethylthiazole 
• 133046-46-5 Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate 
• 20570-36-9 Trifluordithio-essigsaeure 
• 1263286-63-0 ethyl 4-methyl-2-(trifluoromethyl)-1,3-thiazole-5-carboxylate 
• 1402003-85-3 2-[2-(trifluoromethyl)-1,3-thiazol-4-yl]phenol 
• 1384866-42-5 N-[1-(benzoyldithio)-2,2,2-trifluoroethyl]benzamide 
• 936129-78-1 ethyl 5-phenyl-2-(trifluoromethyl)-1,3-thiazole-4-carboxylate 
• 70529-35-0 4,5 bis(4 methoxyphenyl) 2 (trifluoromethyl)thiazole 
• 70529-36-1 4,5-bis-(4-chloro-phenyl)-2-trifluoromethyl-thiazole 
• 70529-37-2 4,5-diphenyl-2-trifluoromethyl-thiazole 
• 7387-69-1 N-benzyl-2,2,2-trifluoroacetamide 
• 131748-96-4 ethyl 2-(trifluoromethyl)thiazole-5-carboxylate 

Relevant articles and documents

Cycloaddition reactions of polyfluoroalkylthioncarboxylic acid derivatives with dimethyl acetylenedicarboxylate (DMAD)

Polyfluoroalkyldithiocarboxylates react with dimethyl acetylenedicarboxylate (DMAD) to give 2-polyfluoroalkyl-1,3-dithioles and/or 2-polyfluoroalkylidene-1,3-dithioles depending on the substituent at the thiolic sulfur atom and on the length of the polyfluoroalkyl chain. Amides of polyfluoroalkylthioncarboxylic acids with DMAD give 2-methoxy-2-polyfluoroalkyl-5-methoxycarbonylmethylene- thiazolidin-4-ones.

HETEROARYL SUBSTITUTED BETA-HYDROXYETHYLAMINES FOR USE IN TREATING HYPERGLYCAEMIA

There is herein provided a compound of formula (I) or a pharmaceutically acceptable salt thereof,wherein the ring containing Q1to Q5, and the groups R1, R2 and R3, have meanings as provided in the description.

BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.