42135-22-8Relevant academic research and scientific papers
Palladium Catalyzed Regioselective Cyclization of Arylcarboxylic Acids via Radical Intermediates with Diaryliodonium Salts
An, Guoqiang,Wang, Limin,Han, Jianwei
, p. 8688 - 8693 (2021/11/24)
Palladium-catalyzed C2-arylation/intramolecular acylation with arylcarboxylic acids was developed by using diaryliodonium salts. The protocol has the advantage of good step-economy by two chemical bonds formation in one pot.
Palladium catalyzed domino C-H activation strategy: An access to 9- fluorenones
Patel, Anuj,Shaikh, Mahommedumar,Chikhalia, Kishor
supporting information, p. 236 - 245 (2018/12/11)
Palladium catalyzed domino C-H functionalization reaction of arylaldehyde with dihaloarene has been developed to access 9-flourenone molecules. Bidentate ligand assisted strategy, single step reaction, high yield and excellent functional group tolerance make this method concise and effective for the synthesis of 9-flourenone. In addition, proposed method has been successfully employed to synthesise Tilorone in gram scale.
Synthesis and radiofluorination of novel fluoren-9-one based derivatives for the imaging of α7 nicotinic acetylcholine receptor with PET
Teodoro, Rodrigo,Scheunemann, Matthias,Wenzel, Barbara,Peters, Dan,Deuther-Conrad, Winnie,Brust, Peter
, p. 1471 - 1475 (2018/04/10)
By structure–activity relationship studies on the tilorone scaffold, the ‘one armed’ substituted dibenzothiophenes and the fluoren-9-ones were identified as the most potential α7 nAChR ligands. While the suitability of dibenzothiophene derivatives as PET tracers is recognized, the potential of fluoren-9-ones is insufficiently investigated. We herein report on a series of fluoren-9-one based derivatives targeting α7 nAChR with compounds 8a and 8c possessing the highest affinity and selectivity. Accordingly, with [18F]8a and [18F]8c we designed and initially evaluated the first fluoren-9-one derived α7 nAChR selective PET ligands. A future application of these radioligands is facilitated by the herein presented successful implementation of fully automated radiosynthesis.
Metallocene compounds, and preparation and use thereof for synthesis of poly-alpha-olefins as lubricating base oil
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Paragraph 0058; 0059, (2018/10/04)
The present invention relates to a metallocene compound, and preparation and use thereof, and the compound can be used as a catalyst for synthesis of poly-α-olefin as lubricating base oil. The metallocene compound includes a substituted aryl group, a bridged atom, an optionally unsubstituted, 3-mono-substituted or 3,6-disubstituted 5H-indeno [1,2-b] pyridyl group or optionally unsubstituted, 3-mono-substituted or 3,6-disubstituted 5H-indeno [1,2-b] thiopyranyl group, and a metal coordination group. As a catalyst, the metallocene compound is shown to be structurally stable and high in catalytic efficiency, and the preparation of the catalyst is relatively easy in operation, high in yield, low in cost, low in pollution and easy to scale up for industrial production.
Containing 3 mono-substituted or 3,6 di substituted fluorenyl metallocene and its preparation method and application (by machine translation)
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Paragraph 0048; 0049, (2016/10/08)
The invention relates to a 3 mono-substituted or 3,6 b-substituted fluorene derivatives and [...] with the framework and the cross-linked metallocene compound and its preparation method and application. Wherein the preparation method comprises the following steps : (1) 3 mono-substituted or 3,6 di-substituted [...][...] in ether with the reaction to prepare fluorenyl/indenyl ligands lithium salt, (2) let fluorenyl/indenyl ligands of lithium salts with alkyl, alkenyl or an organic silyl halide reaction, in order to get the indenyl group in the 3 position with corresponding alkyl, alkenyl or an organic silyl halides of bridge fluorenyl/indenyl ligands ; (3) and a metal compound ligand the reaction may be carried out to obtain the corresponding metal complex metal cyclopentadienyl. The invention discloses a novel fluorenyl metallocene; the preparation method of this invention the synthetic steps are brief, the operation is simple, high yield, raw materials are easy, low cost, environmental pollution is small, is easy for industrial production. (by machine translation)
Electron donor of Ziegler-Natta catalyst and preparation method of electron donor
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Paragraph 0047, (2016/10/10)
The invention relates to an electron donor of a Ziegler-Natta catalyst and a preparation method of the electron donor. Wherein, the preparation method comprises the following steps: reacting 3-monosubstituted or 3, 6-disubstituted fluorene and paraformaldehyde in an organic solvent to generate 9, 9-dihydroxy methyl substituted fluorene, and then carrying out alkylation to generate 9, 9-dialkoxy methyl substituted fluorene. The preparation method disclosed by the invention is short in synthesis step, simple and convenient to operate, high in yield, easily available in raw materials, low in cost, small in environmental pollution, easy for industrial production, and the prepared electron donor has the advantages that the catalysis effect is good when used in a catalysis of polypropylene reaction by the Ziegler-Natta catalyst, and the isotacticity of the generated polypropylene is high.
3-monosubstituted or 3,6-disubstituted fluorene derivative and preparing method and application thereof
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Paragraph 0049-0051, (2017/01/19)
The invention relates to a 3-monosubstituted or 3,6-disubstituted fluorene derivative and a preparing method and application thereof. The preparing method includes the steps that fluorenone is used as a raw material for generating a 9-fluorenone nitro derivative and a 9-fluorenone amino derivative, a diazo-reaction is carried out, an electrophilic substitution or cracking reaction is carried out to generate a 3-monosubstituted or 3,6-disubstituted 9-fluorenone derivative, and the 3-monosubstituted or 3,6-disubstituted 9-fluorenone derivative is reduced to generate the 3-monosubstituted or 3,6-disubstituted fluorene derivative. The preparing method includes simple and short synthesis steps, and is moderate in reaction condition, easy to operate, high in yield, low in cost and small in environment pollution, the raw material is easy to obtain, and industrial production is easy to realize.
Synthesis of fluorenones via quaternary ammonium salt-promoted intramolecular dehydrogenative arylation of aldehydes
Shi, Zhuangzhi,Glorius, Frank
, p. 829 - 833 (2013/03/28)
Biologically interesting fluorenone, xanthone and anthrone derivatives have been prepared via an intramolecular oxidative acylation process. This novel direct acylation reaction proceeded without the aid of any transition metals, acids or bases, and uses a catalytic amount of a quaternary ammonium salt in the presence of a persulfate oxidant. Initial mechanistic studies have been carried out to elucidate the reaction pathway. The Royal Society of Chemistry 2013.
Regioselective ortho-arylation and alkenylation of N-alkyl benzamides with boronic acids via ruthenium-catalyzed C-H bond activation: An easy route to fluorenones synthesis
Chinnagolla, Ravi Kiran,Jeganmohan, Masilamani
supporting information, p. 5246 - 5249,4 (2020/09/02)
A highly regioselective ruthenium-catalyzed ortho-arylation of substituted N-alkyl benzamides with aromatic boronic acids in the presence of [{RuCl 2(p-cymene)}2], AgSbF6, and Ag2O is described. Further, ortho-arylated N-alkyl benzamides were converted into fluorenones in the presence of trifluoroacetic anhydride and HCl.
Pd-catalyzed multiple C-H functionalization to construct biologically active compounds from aryl aldoxime ethers with arenes
Thirunavukkarasu, Vedhagiri S.,Cheng, Chien-Hong
, p. 14723 - 14726 (2012/02/01)
Functional fluorenones: Aromatic aldoxime ethers react with unactivated arenes catalyzed by palladium complexes to give biologically active fluoren-9-ones (see scheme). Multiple C-H bond activation and an oxidative cyclization are involved in the reaction.
