42151-35-9

Basic information

• Product Name: (3E)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)but-3-enoic acid
• Synonyms: butanedioic acid, 2-[(4-methoxyphenyl)methylene]-, 1-methyl ester, (2E)-
• CAS NO: 42151-35-9
• Molecular Formula: C₁₃H₁₄O₅
• Molecular Weight: 250.2473
• Mol File: 42151-35-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 432.7°C at 760 mmHg
• Flash Point: 165°C
• Density: 1.239g/cm³
• Vapor Pressure: 2.95E-08mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: (3E)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)but-3-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3E)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)but-3-enoic acid(42151-35-9)
• EPA Substance Registry System: (3E)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)but-3-enoic acid(42151-35-9)

Safety Data

• Hazardous Substances Data: 42151-35-9(Hazardous Substances Data)

Usage

General Description

The chemical compound "(3E)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)but-3-enoic acid" is a carboxylic acid with a long, complex name. It is a conjugate acid of a (3E)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)but-3-enoate, with a molecular formula of C16H16O5. It is a derivative of but-3-enoic acid with additional functional groups including methoxy and carboxylic acid groups. (3E)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)but-3-enoic acid may have applications in the pharmaceutical and chemical industries, and its specific properties and potential uses would need to be further investigated and researched.

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 106-65-0 Dimethyl succinate 

Downstream Products

• 63151-86-0 (+/-)-2-(4-methoxybenzyl)succinic acid 1-methyl ester 
• 118528-01-1 dihydro-4-[(4-methoxyphenyl)methyl]-2(3H)-furanone 
• 127266-02-8 methyl 4-hydroxy-6-methoxy-2-naphthoate 
• 15822-95-4 4,6-dimethoxy-[2]naphthoic acid methyl ester 
• 90381-47-8 4-acetoxy-6-methoxy-[2]naphthoic acid methyl ester 

Relevant articles and documents

Design and synthesis of novel arctigenin analogues for the amelioration of metabolic disorders

Analogues of the natural product (-)-arctigenin, an activator of adenosine monophosphate activated protein kinase, were prepared in order to evaluate their effects on 2-deoxyglucose uptake in L6 myotubes and possible use in ameliorating metabolic disorders. Racemic arctigenin 2a was found to display a similar uptake enhancement as does (-)-arctigenin. As a result, the SAR study was conducted utilizing racemic compounds. The structure-activity relationship study led to the discovery of key substitution patterns on the lactone motif that govern 2-deoxyglucose uptake activities. The results show that replacement of the para-hydroxyl group of the C-2 benzyl moiety of arctigenin by Cl has a pronounced effect on uptake activity. Specifically, analogue 2p, which contains the p-Cl substituent, stimulates glucose uptake and fatty acid oxidation in L6 myotubes.