421551-82-8

Basic information

• Product Name: Methyl 2-(broMoMethyl)-5-cyanobenzoate
• Synonyms: Methyl 2-(broMoMethyl)-5-cyanobenzoate;2-Bromomethyl-5-cyano-benzoic acid methyl ester
• CAS NO: 421551-82-8
• Molecular Formula: C₁₀H₈BrNO₂
• Molecular Weight: 254.08002
• Mol File: 421551-82-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Methyl 2-(broMoMethyl)-5-cyanobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(broMoMethyl)-5-cyanobenzoate(421551-82-8)
• EPA Substance Registry System: Methyl 2-(broMoMethyl)-5-cyanobenzoate(421551-82-8)

Safety Data

• Hazardous Substances Data: 421551-82-8(Hazardous Substances Data)

Usage

General Description

Methyl 2-(bromomethyl)-5-cyanobenzoate is a chemical compound with the molecular formula C10H8BrNO2. It is a cyanobenzoate derivative that contains a bromomethyl group and a cyanide group. Methyl 2-(broMoMethyl)-5-cyanobenzoate is commonly used as an intermediate in organic synthesis and is also used in the pharmaceutical industry. It is important to handle this chemical with caution, as it is known to be toxic and potentially harmful if ingested or inhaled. Additionally, it may also be a skin and eye irritant. Therefore, proper safety precautions and handling procedures should always be followed when working with methyl 2-(bromomethyl)-5-cyanobenzoate.

Upstream product

• 103261-68-3 5-cyano-2-methylbenzoic acid methyl ester 
• 79669-50-4 methyl 2-methyl-5-bromobenzoate 
• 79669-49-1 5-bromo-2-methylbenzoic acid 
• 60710-80-7 5-cyano-2-methylaniline 
• 39478-78-9 5-bromo-2-methylaniline 
• 18595-12-5 methyl 5-amino-2-methylbenzoate 
• 77324-87-9 methyl 2-methyl-5-nitrobenzoate 
• 1975-52-6 5-nitro-o-toluic acid 
• 42872-79-7 3-iodo-4-methylbenzonitrile 

Downstream Products

• 668262-50-8 methyl 2-{[bromo(triphenyl)phosphoranyl]methyl}-5-cyanobenzoate 
• 678992-36-4 5-[5-(5-cyano-1-oxo-1,3-dihydro-isoindol-2-ylmethyl)-3-methyl-1H-pyrazol-4yloxy]-isophthalonitrile 
• 1261726-80-0 3-oxoisoindoline-5-carbonitrile 

Relevant articles and documents

ISOINDOLINONE COMPOUNDS

Disclosed herein is a compound or pharmaceutically acceptable salts or stereoisomers thereof of of formula I wherein X1 is linear or branched C1-6 alkyl, C3-6 cycloalkyl, -C1-6 alkyl C3-6 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C1-6 alkyl C6-10 aryl, C1-6 alkyl 5-10 membered heteroaryl, wherein X1 is unsubstituted or substituted with one or more of halogen, linear or branched C1-6 alkyl, linear or branched C1-6 heteroalkyl, CF3, CHF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C1-6 alkylamino, -CN, -N(H)C(O)-C1- 6alkyl, -OC(O)-C1-6alkyl, -OC(O)-C1-4alkylamino, -C(O)O-C1-6alkyl, -COOH, - CHO, -C1-6alkylC(O)OH, -C1-6alkylC(O)O-C1-6alkyl, NH2, C1-6 alkoxy or C1-6 alkylhydroxy; X2 is hydrogen, C6-10 aryl, 5-10 membered heteroaryl, -O-(5-10 membered heteroaryl), 4-8 membered heterocycloalkyl, C1-4 alkyl 4-8 membered heterocycloalkyl, -O-(4-8 membered heterocycloalkyl), -O-C1-4 alkyl-(4-8 membered heterocycloalkyl), -OC(O)-C1-4alkyl-4-8 membered heterocycloalkyl or C6 aryloxy, wherein X2 is unsubstituted or substituted with one or more of linear or branched C1-6 alkyl, NH2, NMe2 or 5-6 membered heterocycloalkyl; n is 0, 1 or 2.

HETEROCYCLIC COMPOUND

The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerati

Preparation of novel anthranilic acids as antibacterial agents. Extensive evaluation of alternative amide bioisosteres connecting the A- and the B-rings

In the past few years, a significant effort has been devoted by Pharmacia toward the discovery of novel antibiotics. We have recently described the identification of an anthranilic acid lead 1 and the optimization resulting in the advanced lead 2. In this report, we describe the preparation of several selected amide bioisosteres connecting the A- and the B-rings. The E-alkene provided a rigid analog with equal potency to the corresponding amide. This indicates that the amide is not a recognition element rather acts as an appropriate spatial linker of the two important aryl A and B rings. The work here clearly demonstrates that the amide linker can be replaced with several functionalities without significant deterioration in the MIC activity.