421558-77-2

Basic information

• Product Name: 2-Nitro-5-(piperidin-1-yl)benzaMide
• Synonyms: 2-Nitro-5-(piperidin-1-yl)benzaMide
• CAS NO: 421558-77-2
• Molecular Formula: C₁₂H₁₅N₃O₃
• Molecular Weight: 249.2658
• Mol File: 421558-77-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Nitro-5-(piperidin-1-yl)benzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Nitro-5-(piperidin-1-yl)benzaMide(421558-77-2)
• EPA Substance Registry System: 2-Nitro-5-(piperidin-1-yl)benzaMide(421558-77-2)

Safety Data

• Hazardous Substances Data: 421558-77-2(Hazardous Substances Data)

Usage

Description

2-Nitro-5-(piperidin-1-yl)benzamide is a chemical compound with the molecular formula C14H17N3O3. It is a nitroaromatic compound that contains a piperidine ring. 2-Nitro-5-(piperidin-1-yl)benzaMide is known for its reactivity and is susceptible to nitrosylation, reduction, and nitro-group displacement reactions. It is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
2-Nitro-5-(piperidin-1-yl)benzamide is used as a building block for the synthesis of various pharmaceuticals. It is known for its antitumor and anti-inflammatory activities, making it a promising candidate for the development of new medications.
Used in Agrochemical Industry:
2-Nitro-5-(piperidin-1-yl)benzamide is also used as a building block in the synthesis of agrochemicals. Its versatile applications and potential therapeutic properties make it an important chemical for the agrochemical industry as well.

Upstream product

• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 455-38-9 3-fluorobenzoic acid 
• 110-89-4 piperidine 
• 77206-97-4 2-nitro-5-fluorobenzamide 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 
• 40763-96-0 2-nitro-5-chlorobenzamide 
• 41994-44-9 5-chloro-2-nitrobenzoyl chloride 

Downstream Products

• 314768-97-3 2-amino-5-(piperidin-1-yl)benzamide 

Relevant articles and documents

2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn)

Swapping the substituents in positions 2 and 4 of the previously synthesized but yet undisclosed 5-cyano-4-(methylthio)-2-arylpyrimidin-6-ones 4, ring closure, and further optimization led to the identification of the potent antitubercular 2-thio-substituted quinazolinone 26. Structure-activity relationship (SAR) studies indicated a crucial role for both meta-nitro substituents for antitubercular activity, while the introduction of polar substituents on the quinazolinone core allowed reduction of bovine serum albumin (BSA) binding (63c, 63d). While most of the tested quinazolinones exhibited no cytotoxicity against MRC-5, the most potent compound 26 was found to be mutagenic via the Ames test. This analogue exhibited moderate inhibitory potency against Mycobacterium tuberculosis thymidylate kinase, the target of the 3-cyanopyridones that lies at the basis of the current analogues, indicating that the whole-cell antimycobacterial activity of the present S-substituted thioquinazolinones is likely due to modulation of alternative or additional targets. Diminished antimycobacterial activity was observed against mutants affected in cofactor F420 biosynthesis (fbiC), cofactor reduction (fgd), or deazaflavin-dependent nitroreductase activity (rv3547), indicating that reductive activation of the 3,5-dinitrobenzyl analogues is key to antimycobacterial activity.

Molecular modelling, synthesis, cytotoxicity and anti-tumour mechanisms of 2-aryl-6-substituted quinazolinones as dual-targeted anti-cancer agents

Background and Purpose Our previous study demonstrated that 6-(pyrrolidin-1-yl)-2-(3-methoxyphenyl)quinazolin-4-one (HMJ38) was a potent anti-tubulin agent. Here, HMJ38 was used as a lead compound to develop more potent anti-cancer agents and to examine t

Synthesis and preliminary cytotoxic and antifungal evaluation of some 6-N,N-dialkyl 2-aryl-4(3H)-quinazolinone derivatives

Some new 2-aryl-4-quinazolinone derivatives bearing a cyclic amino group at position 6 were prepared and their preliminary cytotoxic and antifungal evaluation is reported. They all showed a moderate cytotoxicity suggesting that not only the oxidation stat