42156-70-7

Basic information

• Product Name: 3-(4-(dimethylamino)phenyl)-3-hydroxy-2-methylisoindolin-1-one
• Synonyms: 3-(4-(dimethylamino)phenyl)-3-hydroxy-2-methylisoindolin-1-one
• CAS NO: 42156-70-7
• Molecular Weight: 282.342
• Mol File: 42156-70-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-(dimethylamino)phenyl)-3-hydroxy-2-methylisoindolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-(dimethylamino)phenyl)-3-hydroxy-2-methylisoindolin-1-one(42156-70-7)
• EPA Substance Registry System: 3-(4-(dimethylamino)phenyl)-3-hydroxy-2-methylisoindolin-1-one(42156-70-7)

Safety Data

• Hazardous Substances Data: 42156-70-7(Hazardous Substances Data)

Upstream product

• 59325-17-6 ethyl benzyl(methyl)carbamate 
• 5342-91-6 2-methylisoindolin-1-one 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 103-67-3 benzyl-methyl-amine 

Relevant articles and documents

Tandem C(sp3)?H Arylation/Oxidation and Arylation/Allylic Substitution of Isoindolinones

Isoindolinones comprise an important class of medicinally active compounds. Herein we report a straightforward functionalization of isoindolinones with aryl bromides (22 examples) using a palladium(II) acetate/NIXANTPHOS-based catalyst system. Additionally 3-aryl-3-hydroxyisoindolinone derivatives, which exhibit anti-tumor activity, can be accessed via a tandem reaction. Thus, when the arylation product is exposed to air under basic conditions, in situ oxidation takes place to install the 3-hydroxy group. Furthermore, a tandem arylation/allylic substitution reaction is advanced in which both the arylation and allylic substitution are catalyzed by the same palladium catalyst. Finally, a tandem arylation/alkylation procedure is presented. These tandem reactions enable the synthesis of a variety of structurally diverse isoindolinone derivatives from common starting materials. (Figure presented.).