5342-91-6

Basic information

• Product Name: 2-METHYLISOINDOLIN-1-ONE
• Synonyms: 2-METHYLISOINDOLIN-1-ONE;2-Methyl-2,3-dihydro-isoindol-1-one
• CAS NO: 5342-91-6
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Mol File: 5342-91-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 288.1°C at 760 mmHg
• Flash Point: 135.3°C
• Appearance: /
• Density: 1.167g/cm³
• Vapor Pressure: 0.00239mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 2-METHYLISOINDOLIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLISOINDOLIN-1-ONE(5342-91-6)
• EPA Substance Registry System: 2-METHYLISOINDOLIN-1-ONE(5342-91-6)

Safety Data

• Hazardous Substances Data: 5342-91-6(Hazardous Substances Data)

Usage

General Description

2-METHYLISOINDOLIN-1-ONE is a chemical compound with the molecular formula C9H9NO. It is an organic compound that is classified as an isoindoline, which is a nitrogen heterocycle. 2-METHYLISOINDOLIN-1-ONE is also known as 2-methyl-1,3-dihydro-2H-isoindol-1-one and is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has a white to off-white crystalline appearance and is sparingly soluble in water, but soluble in organic solvents such as ethanol and ether. 2-METHYLISOINDOLIN-1-ONE has applications in the production of dyes, pigments, and other specialty chemicals.

InChI:InChI=1/C9H9NO/c1-10-6-7-4-2-3-5-8(7)9(10)11/h2-5H,6H2,1H3

Upstream product

• 550-44-7 N-methylphthalimide 
• 103-67-3 benzyl-methyl-amine 
• 111-66-0 oct-1-ene 
• 56475-82-2 methyl N-benzyl,N-methyl carbamate 
• 160094-23-5 n-propyl benzyl(methyl)carbamate 
• 104272-97-1 propan-2-yl benzyl(methyl)carbamate 
• 592-41-6 1-hexene 
• 64-17-5 ethanol 
• 7664-93-9 sulfuric acid 
• 7732-18-5 water 
• 82435-80-1 N-chloro-N-methyl-α-chloroorthotoluamide 
• 67-64-1 acetone 

Downstream Products

• 564467-88-5 1-benzyl-2-methyl-isoindole 
• 51802-87-0 2-methyl-1-phenyl-isoindole 
• 3474-87-1 2-methylisoindoline 
• 564467-91-0 2-methyl-6-nitroisoindolin-1-one 
• 464-72-2 tetraphenylethane-1,2-diol 
• 82480-88-4 N-methyl diphenylcarbinyl-3 phtalimidine 
• 550-44-7 N-methylphthalimide 
• 86770-02-7 3-Benzyl-2,3-dihydro-2-methyl-1H-isoindol-1-one 
• 119-65-3 isoquinoline 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 40523-35-1 (3E)-3-benzylidene-2-methylisoindolin-1-one 
• 93273-16-6 2-Phenyl-1-ethylthioisoindole 
• 93273-28-0 C₂₇H₂₄N₂O₃S 

Relevant articles and documents

Smooth isoindolinone formation from isopropyl carbamates via bischler-napieralski-type cyclization

Isopropyl carbamates derived from benzylamines provide isoindolinones by treatment with phosphorus pentoxide at room temperature. Utility of this Bischler-Napieralski-type cyclization and a new mechanism involving a carbamoyl cation for rationalization of this smooth conversion are discussed.

Reactivity of Carbamoyl Radicals. A New, General, Convenient Free-Radical Synthesis of Isocyanates from Monoamides of Oxalic Acid

A new, general, simple synthesis of isocyanates was developed by oxidation of monoamides of oxalix acid with peroxydisulfate catalyzed by Ag and Cu salts.The reaction was carried out in a two-phase system (water and an organic solvent), and it is suitable also for practical applications, due to the simple experimental conditions and the inexpensive as well as nontoxic reagents.The first example of homolytic intramolecular aromatic carbamoylation is also reported.