5342-91-6

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYLISOINDOLIN-1-ONE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to form complex molecular structures that can target specific biological pathways. Its unique properties allow it to be incorporated into a wide range of medicinal compounds, enhancing their efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, 2-METHYLISOINDOLIN-1-ONE is utilized as a precursor in the development of pesticides and other crop protection agents. Its chemical structure contributes to the creation of molecules that can effectively combat pests and diseases, thereby improving crop yields and quality.
Used in Dye and Pigment Production:
2-METHYLISOINDOLIN-1-ONE is used as a starting material in the production of dyes and pigments due to its ability to form stable and vibrant color compounds. These dyes and pigments find applications in various industries, including textiles, plastics, and printing inks, where colorfastness and resistance to environmental factors are essential.
Used in Specialty Chemicals:
2-METHYLISOINDOLIN-1-ONE also has applications in the production of specialty chemicals, where its unique chemical properties can be harnessed to create high-performance materials for specific industrial applications. These may include advanced materials for coatings, adhesives, or other chemical intermediates that require tailored properties for their intended use.

InChI:InChI=1/C9H9NO/c1-10-6-7-4-2-3-5-8(7)9(10)11/h2-5H,6H2,1H3

Upstream product

• 550-44-7 N-methylphthalimide 
• 64-17-5 ethanol 
• 7664-93-9 sulfuric acid 
• 7732-18-5 water 
• 67-64-1 acetone 
• 592-41-6 1-hexene 
• 104272-97-1 propan-2-yl benzyl(methyl)carbamate 
• 111-66-0 oct-1-ene 
• 160094-23-5 n-propyl benzyl(methyl)carbamate 
• 56475-82-2 methyl N-benzyl,N-methyl carbamate 
• 103-67-3 benzyl-methyl-amine 
• 82435-80-1 N-chloro-N-methyl-α-chloroorthotoluamide 

Downstream Products

• 564467-88-5 1-benzyl-2-methyl-isoindole 
• 51802-87-0 2-methyl-1-phenyl-isoindole 
• 3474-87-1 2-methylisoindoline 
• 564467-91-0 2-methyl-6-nitroisoindolin-1-one 
• 464-72-2 tetraphenylethane-1,2-diol 
• 82480-88-4 N-methyl diphenylcarbinyl-3 phtalimidine 
• 550-44-7 N-methylphthalimide 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 40523-35-1 (3E)-3-benzylidene-2-methylisoindolin-1-one 
• 93273-16-6 2-Phenyl-1-ethylthioisoindole 
• 93273-28-0 C₂₇H₂₄N₂O₃S 
• 34713-20-7 3-(4-chlorophenyl)-2-methylisoindolin-1-one 

Relevant academic research and scientific papers

Smooth isoindolinone formation from isopropyl carbamates via bischler-napieralski-type cyclization

Isopropyl carbamates derived from benzylamines provide isoindolinones by treatment with phosphorus pentoxide at room temperature. Utility of this Bischler-Napieralski-type cyclization and a new mechanism involving a carbamoyl cation for rationalization of this smooth conversion are discussed.

The photodecarboxylative addition of carboxylates to phthalimides: Scope and limitations

Intermolecular photoinduced decarboxylative additions of a series of alkylcarboxylates to N-substituted phthalimides gave the corresponding hydroxyphthalimidines in moderate to high yields of 39-89%. The potassium salt of 1-adamantanecarboxylic acid predominately underwent simple decarboxylation when irradiated in the presence of N-methylphthalimide. In case of phthalimides carrying suitable leaving groups within the N-side chain, decarboxylation, retro-Aldol cleavage or decarbonylation preceded the intermolecular addition step.

Reactivity of Carbamoyl Radicals. A New, General, Convenient Free-Radical Synthesis of Isocyanates from Monoamides of Oxalic Acid

A new, general, simple synthesis of isocyanates was developed by oxidation of monoamides of oxalix acid with peroxydisulfate catalyzed by Ag and Cu salts.The reaction was carried out in a two-phase system (water and an organic solvent), and it is suitable also for practical applications, due to the simple experimental conditions and the inexpensive as well as nontoxic reagents.The first example of homolytic intramolecular aromatic carbamoylation is also reported.

The mechanism of electrochemical reduction of N-haloamides in acetonitrile: trapping of intermediate amide anions and father-son protonation

The electrochemical reduction of N-haloamides (ZCONRX) in acetonitrile involves two consecutive one-electron transfers and generates the amide anions.Attempts to trap the intermediate amidyl radical resulting from first electron transfer were unssuccesful.In the case of the N-halo-N-hydroamides (R=H), the amide anion formed at the electrode abstracts a proton from an incoming N-halo-N-hydroamide molecule to give the parent amide and the conjugate base of the N-haloamide (father-son protonation).Thus, half of the N-halo-N-hydroamide reaching the electrode is reduced, the other half being converted to its conjugate base.In acetonitrile-LiClO4 (0.2 M) containing 0.2percent water, the conjugate base is reducible and polarograms therefore show two waves (irreversible and diffusion controlled) of equivalent intensities due respectively to the reduction of the N-halo-N-hydroamide and to the reduction of its conjugate base.In the case of the N-chloro-N-alkyl(aryl)amides (X=Cl, R=alkyl or aryl), the amide anion abstracts a proton from the medium to give the parent amide and anionic species that react with the starting N-chloroamide regenerating the amide anion.Hence, the coulometric results are low (0.5 F/mol).However, in the presence of acetic acid, the reduction consumes 2 F/mol as expected.The N-alkylamide anion has been trapped by N-alkylation and N-acylation.The voltammograms of N-chloro-N-alkyl(aryl)amides show multiple waves on mercury and platinum due to passivation-adsorption phenomena but a single wave on vitreous carbon.