421575-94-2Relevant academic research and scientific papers
Synthesis, structure, and antimicrobial activity of N,6-diaryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides
Gein,Zamaraeva,Fedotov, A. Yu.,Balandina,Dmitriev
, (2016)
Reactions of acetoacetic acid N-arylamides with aromatic aldehydes and urea led to the formation of N,6-diaryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. Structure and antimicrobial activity of the compounds obtained were examined.
Synthesis of Biginelli compounds using cobalt hydrogen sulfate
Memarian, Hamid Reza,Ranjbar, Mahnaz
experimental part, p. 522 - 527 (2012/01/05)
Efficient synthesis of various 2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidines containing acetyl, carboethoxy, carbomethoxy and carboxamide groups on 5-position of the M-substituted and ATL-unsubstituted heterocyclic ring was achieved using cobalt hydrogen su
Synthesis of 3,4-Dihydropyrimidin-2(1H)-one-5-carboxamides
Soleymani, Mousa,Memarian, Hamid Reza
experimental part, p. 485 - 492 (2010/10/02)
The synthesis of various dihydropyrimidinone derivatives bearing carbamoyl moieties in 5-position under reflux conditions and microwave irradiation is described. An efficient three-component Biginelli reaction using catalytic amounts of zirconium(IV) chlo
Novel Biginelli dihydropyrimidines with potential anticancer activity: A parallel synthesis and CoMSIA study
Prashantha Kumar,Sankar, Gopu,Nasir Baig,Chandrashekaran, Srinivasan
experimental part, p. 4192 - 4198 (2009/12/06)
Novel Biginelli dihydropyrimidines of biological interest were prepared using p-toluene sulphonic acid as an efficient catalyst. All the thirty-two synthesised dihydropyrimidines were evaluated for their in vitro antioxidant activity using DPPH method. Only, compounds 28 and 29 exhibited reasonably good antioxidant activity. Furthermore, the synthesised Biginelli compounds were subjected for their in vitro anticancer activity against MCF-7 human breast cancer cells. The title compounds were tested at the concentration of 10 μg. Compounds exhibited activity ranging from weak to moderate and, from moderate to high in terms of percentage cytotoxicity. Among them, compounds 10 and 11 exhibited significant anticancer activity. In order to elucidate the three-dimensional structure-activity relationships (3D QSAR) towards their anticancer activity, we subjected them for comparative molecular similarity indices analysis (CoMSIA). Illustration regarding their synthesis, analysis, antioxidant activity, anticancer activity and 3D QSAR study is described.
