42160-07-6

Usage

Uses

Used in Pharmaceutical Research:
1,5-Bis(4-trifluoromethylphenyl)-penta-1,4-diene-3-one is used as a reagent or intermediate in the production of various pharmaceutical drugs. Its trifluoromethylphenyl groups make it highly reactive and versatile in various chemical reactions, making it a valuable compound in the field of organic chemistry.
Used in Agrochemicals:
1,5-Bis(4-trifluoromethylphenyl)-penta-1,4-diene-3-one is also used in the production of agrochemicals, where its reactivity and versatility contribute to the development of effective products.
Used in Chemical Research:
1,5-Bis(4-trifluoromethylphenyl)-penta-1,4-diene-3-one has been studied for its potential biological activities and medicinal applications, further adding to its significance in the field of chemical research.

InChI:InChI=1/C19H12F6O/c20-18(21,22)15-7-1-13(2-8-15)5-11-17(26)12-6-14-3-9-16(10-4-14)19(23,24)25/h1-12H

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 67-64-1 acetone 

Downstream Products

• 1309883-48-4 ethyl (2R,6R)-2',4-dioxo-2,6-bis(4-(trifluoromethyl)phenyl)spiro[cyclohexane-1,3'-indoline]-1'-carboxylate 
• 1374637-18-9 C₂₇H₁₉F₆NO₂ 
• 1053242-55-9 1,5-bis[4-(trifluoromethyl)phenyl]-3-pentanone 
• 67485-29-4 hydramethylnon 
• 1290622-38-6 4-nitro-3,5-di(4-trifluoromethylphenyl) cyclohexanone 
• 1262238-66-3 (2S,6S)-4-oxo-2,6-bis(4-(trifluoromethyl)phenyl)cyclohexane-1,1-dicarbonitrile 

Relevant academic research and scientific papers

Silica gel-mediated self-aldol reactions of highly volatile aldehydes under organic solvent-free conditions without reflux condenser

Silica gel-mediated self-aldol reactions were catalyzed by piperidine to give the corresponding α,β-conjugated aldehydes in good yields. The aldol reactions of 4-nitro-, 4-trifluoromethyl-, and 4-chlorobenzaldehydes with acetone afforded the corresponding aldol products. Highly volatile aldehydes and acetone could be employed even without a reflux condenser for these reactions. Silica gel could be recycled five times without any significant decrease of the yields of the products.

A process for synthesizing [...] (by machine translation)

The present invention provides a process for synthesizing [...], including 2-hydrazino -5,5-dimethyl -1, 4, 5, 6-Tetrahydropyrimidines, their production and use hydrochloric acid salt and 1,5-bis-(4-trifluoromethyl phenyl) - 1,4-pentadiene-3-ketone preparation, and the raw material to the two, to isopropanol or ethanol as the solvent, the role of the concentrated hydrochloric acid produces [...]. By changing the synthesis process of the present invention, the reaction efficiency is improved. 2-hydrazino -5,5-dimethyl -1, 4, 5, 6-Tetrahydropyrimidines, their production and use the yield of the hydrochloride salt from 78% to 90% or more. 1,5-double (4-trifluoromethyl phenyl) - 1,4-pentadiene-3-one of the from the literature reports the yield of 83% to 90% or more. (by machine translation)

Tandem hydrogenation and condensation of fluorinated α,β-unsaturated ketones with primary amines, catalyzed by nickel

A simple homogeneous catalytic system based on nickel phosphine complexes has been developed for the transfer hydrogenation and condensation of α,β-unsaturated ketones to yield saturated ones and saturated imines using primary amines as hydrogen donors. Thus, a wide range of fluorinated 1,5-diaryl-1,4-pentadiene-3-ones were allowed to react with substituted benzylamines in the presence of [(dippe)Ni(μ-H)]2 (dippe = 1,2-bis-(diisopropylphosphino)-ethane) using ethanol as a solvent at 180 °C to give the corresponding saturated carbonyl compounds; here hydrogenation of the CC bond was preferred over the CO bond. Under the same reaction conditions but using an excess of benzylamine, a tandem process is then favoured, starting also with the reduction of the CC bond followed by a nucleophilic addition of the primary amine to yield valuable saturated imines with good to excellent yields (62%-91%).