42174-82-3Relevant academic research and scientific papers
Copper-catalyzed synthesis of α,β-unsaturated acylamides via direct amidation from cinnamic acids and N-substituted formamides
Yan, Hong,Yang, Hailong,Lu, Linhua,Liu, Defu,Rong, Guangwei,Mao, Jincheng
supporting information, p. 7258 - 7263 (2013/08/23)
A highly effective synthesis of α,β-unsaturated acylamides is reported for the first time via copper-catalyzed direct amidation between readily available cinnamic acids and N-substituted formamides. The protocol was easily accessible and practical.
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells
Germain, Andrew R.,Carmody, Leigh C.,Nag, Partha P.,Morgan, Barbara,Verplank, Lynn,Fernandez, Cristina,Donckele, Etienne,Feng, Yuxiong,Perez, Jose R.,Dandapani, Sivaraman,Palmer, Michelle,Lander, Eric S.,Gupta, Piyush B.,Schreiber, Stuart L.,Munoz, Benito
supporting information, p. 1834 - 1838 (2013/04/10)
A high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from the National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository (MLSMR). A cinnamide analog displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE-sh-Ecad) over the isogenic control cell line (HMLE-sh-eGFP). Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations.
