42187-27-9Relevant academic research and scientific papers
Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease
Catalano, Susan M.,Huang, Yaodong,Izzo, Nicholas J.,Labarbera, Kelsie M,Limegrover, Colleen S.,Look, Gary C.,Ni, Zhi-Jie,Rehak, Courtney,Rishton, Gilbert M.,Wang, Yingcai,Wu, Xiaodong,Yurko, Raymond,Zhang, Jason
supporting information, p. 1389 - 1395 (2021/08/31)
An unbiased phenotypic neuronal assay was developed to measure the synaptotoxic effects of soluble Aβ oligomers. A collection of CNS druglike small molecules prepared by conditioned extraction was screened. Compounds that prevented and reversed synaptotox
ISOINDOLINE COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
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Paragraph 0533; 0541, (2015/09/23)
Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta- associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.
