422-67-3

Usage

Uses

Used in Chemical Synthesis:
Acetic acid, difluorosulfois used as a reagent in chemical synthesis for its unique properties and reactivity profile.
Used in Pharmaceuticals:
Acetic acid, difluorosulfois used as a pharmaceutical intermediate for the development of new drugs.
Used in Industrial Processes:
Acetic acid, difluorosulfois used as a reagent in various industrial processes due to its unique properties and reactivity profile.
It is important to handle this chemical with care, as it may be corrosive and harmful if not used properly.

Upstream product

• 677-67-8 fluorosulfonyldifluoroacetyl fluoride 
• 697-18-7 tetrafluoroethane-β-sultone 
• 1717-59-5 2,2-difluoro-2-(fluorosulfonyl)acetic acid 
• 1310-73-2 sodium hydroxide 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 

Downstream Products

• 18225-64-4 methyl 2,2-difluoro-2-sulfoacetate 
• 899452-26-7 5-bromo-2-(difluoromethoxy)pyridine 

Relevant academic research and scientific papers

Redox-Neutral Tetrafluoroethylation of Aryl Alkynes with 1,1,2,2-Tetrafluoroethane Sulfonic Acid Leading to α-Tetrafluoroethylated Acetophenones

The redox-neutral tetrafluoroethylation of alkynes with 1,1,2,2-tetrafluroroethanesulfonic acid (TFESA) and azobis(isobutyronitrile) (AIBN) proceeds via the formation of vinyl tetrafluoroethanesulfonates followed by a radical tetrafluoroethylation. Experimental and theoretical results support an intermolecular reaction.

Photoredox-catalyzed tandem radical cyclization of N-arylacrylamides: General methods to construct fluorinated 3,3-disubstituted 2-oxindoles using fluoroalkylsulfonyl chlorides

Fluorinated radicals were generated from RfSO2Cl by photoredox catalysis under mild conditions, where Rf = n-C4F9, CF3, CF2H, CH2F, CH2CF3, and CF2CO2Me. This method provided a general way to construct fluorinated 2-oxindoles from reaction with N-arylacrylamides via a proposed tandem radical cyclization process.

AN IMPROVED METHOD FOR SYNTHESIZING DIFLUOROMETHANESULFONIC ACID

In the presence of catalytic amounts of sodium sulfate or sodium chloride, fluorosulfonyldifluoroacetic acid (1) was decarboxylated in CH3CN-H2O to give difluoromethanesulfonyl fluoride (2) in moderate yield. 2 can be completely hydrolyzed to the corresponding acid 3 at 80 deg C to 100 deg C.The overall yield of 3 from 1 was 53percent.