42204-43-3

Upstream product

• 51255-17-5 1-O-methyl-2-deoxy-D-ribofuranoside 
• 6698-29-9 5′-O-toluenesulphonyl-2′-deoxyadenosine 
• 149284-20-8 methyl 5-azido-2,5-dideoxy-β-D-erythro-pentofuranoside 
• 158603-53-3 methyl 3-O-acetyl-5-azido-2,5-dideoxy-β-D-erythro-pentofuranoside 
• 60251-58-3 methyl 2-deoxy-5-O-(p-toluenesulfonyl)-β-D-erythro-pentofuranoside 
• 158603-55-5 Acetic acid (2R,3S,5R)-2-azidomethyl-5-(6-isobutyrylamino-purin-9-yl)-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

Synthesis of bioconjugated sym -pentasubstituted corannulenes: Experimental and theoretical investigations of supramolecular architectures

Applications of supramolecular architectures span a broad range of fields from medicinal chemistry to materials science and gas storage, making the design and synthesis of such structures a goal of high interest. The unique structural and symmetric proper

5'-Azido and 5'-fluoro alpha-nucleosides as analogues of AZT and FLT.

5-Azido-2,5-dideoxy-beta-D-erythro-pentofuranosyl nucleosides 10 and their corresponding alpha-anomers 11 have been synthesized by condensation of methyl 3-O-acetyl-5-azido-2,5-dideoxy-beta-D-erythro-pentofuranoside (7) with silylated nucleobases followed by deprotection with methanolic ammonia. Reaction of silylated thymine (19) with methyl 2,3-di-O-benzoyl-5-deoxy-5-fluoro-D-arabino-pentofuranoside (15) and methyl 5-azido-2,3-di-O-benzoyl-5-deoxy-alpha-D-arabino-pentofuranoside (17 alpha) afforded a mixture of the alpha-nucleosides 20 and the acyclo nucleosides 5-fluoro- and 5-azido-2,3-O-dibenzoyl-5-deoxy-1-O-methyl-1-(thymin-1-yl)-D -arabinitol (22). Compounds 20 and 22 were deprotected with methanolic ammonia to give the acyclic nucleosides 21 and 23, respectively. The new nucleosides were inactive against HSV-1 and HIV-1.