422268-10-8Relevant articles and documents
The enantioselective synthesis of APTO and AETD: Polyhydroxylated β-amino acid constituents of the microsclerodermin cyclic peptides
Shuter, Emily C.,Duong, Hung,Hutton, Craig A.,McLeod, Malcolm D.
, p. 3183 - 3189 (2007)
The polyhydroxylated β-amino acids (2S,3R,4S,5S,7E)-3-amino-8-phenyl- 2,4,5-trihydroxyoct-7-enoic acid (APTO) and (2S,3R,4S,5S,7E,9E)-3-amino-10-(4- ethoxyphenyl)-2,4,5-trihydroxydeca-7,9-dienoic acid (AETD) are key components of the microsclerodermin fam
Methods to manufacture 1,3-dioxolane nucleosides
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Page/Page column 16; 17, (2008/06/13)
This application provides a process for preparing enantiomerically pure β-D-dioxolane nucleosides. In particular, a new synthesis of (?)-DAPD, suitable for large scale development, is described. In one embodiment the invention provides a process for prepa