422280-47-5Relevant academic research and scientific papers
Rhodium-catalyzed addition-spirocyclization of arylboronic esters containing β-aryl α,β-unsaturated ester Moiety
Matsuda, Takanori,Yasuoka, Satoshi,Watanuki, Shoichi,Fukuhara, Keisuke
, p. 1338 - 1338 (2015)
Abstract In this study, we developed a rhodium(I)-catalyzed spiro-cyclization. The reaction includes 1,4-rhodium migration and provides a route for forming spirocyclic 1-indanones.
Substituted alkanoic acids
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Page 38, (2010/02/05)
The invention is directed to physiologically active compounds of general formula (I): wherein:- represents (i) a saturated 3 to 6 membered carbocycle, optionally substituted by one or more alkyl groups, (ii) indanyl or (iii) a saturated 4 to 6 membered heterocyclic ring; R1 represents R3Z1-Het- or R4N(R5)—C(═O)—NH—Ar1—; L1 represents an —R6—R7— linkage; R2 represents hydrogen, halogen, lower alkyl or lower alkoxy; L2 represents an alkylene linkage; Y is carboxy or an acid bioisostere; and their corresponding N-oxides or prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their corresponding N-oxides or prodrugs. Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with the integrin VLA-4 (α4β1).
