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2-Chloro-8-methylquinoline, with the molecular formula C10H8ClN, is an aromatic compound characterized by a quinoline ring with a chlorine atom at the 2-position and a methyl group at the 8-position. This versatile chemical is recognized for its potential as an anti-inflammatory and anti-cancer agent, making it a subject of interest in biological and pharmacological research.

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  • 4225-85-8 Structure
  • Basic information

    1. Product Name: 2-Chloro-8-methylquinoline
    2. Synonyms: 2-Chloro-8-methylquinoline
    3. CAS NO:4225-85-8
    4. Molecular Formula: C10H8ClN
    5. Molecular Weight: 177.63022
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 4225-85-8.mol
  • Chemical Properties

    1. Melting Point: 61°C
    2. Boiling Point: 292.84°C (rough estimate)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.1810 (rough estimate)
    6. Refractive Index: 1.6224 (estimate)
    7. Storage Temp.: Inert atmosphere,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Chloro-8-methylquinoline(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Chloro-8-methylquinoline(4225-85-8)
    11. EPA Substance Registry System: 2-Chloro-8-methylquinoline(4225-85-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 4225-85-8(Hazardous Substances Data)

4225-85-8 Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-8-methylquinoline is utilized as a building block in the synthesis of pharmaceutical drugs, contributing to the development of new therapeutic agents.
Used in Organic Synthesis:
2-Chloro-8-methylquinoline serves as a reagent in organic synthesis, facilitating the creation of various chemical products through its reactive properties.
Used in Agrochemical Production:
2-Chloro-8-methylquinoline is employed as an intermediate in the production of agrochemicals, playing a crucial role in the development of agricultural products.
Used in Research and Development:
2-Chloro-8-methylquinoline is used as a subject of research for its biological and pharmacological properties, with a focus on its potential as an anti-inflammatory and anti-cancer agent, indicating its importance in advancing medical science.

Check Digit Verification of cas no

The CAS Registry Mumber 4225-85-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,2 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4225-85:
(6*4)+(5*2)+(4*2)+(3*5)+(2*8)+(1*5)=78
78 % 10 = 8
So 4225-85-8 is a valid CAS Registry Number.

4225-85-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloro-8-methylquinoline

1.2 Other means of identification

Product number -
Other names 2-Chlor-8-methyl-chinolin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4225-85-8 SDS

4225-85-8Relevant articles and documents

C-Bridged Bispyrrolidines and Bispiperidines as New Ligands

Stumpf, Tim-Daniel J.,Steinbach, Manfred,H?ltke, Magdalene,Heuger, Gerold,Grasemann, Franka,Fr?hlich, Roland,Schindler, Siegfried,G?ttlich, Richard

, p. 5538 - 5547 (2018/10/25)

The preparation of methylene-bridged C2-symmetric nitrogen-heterocycles as a new class of ligands is described, including methylene-bridged pyridines, quinolones, piperidines and pyrrolidines. These methylene-bridged aromatic systems are obtained via a microwave assisted Ziegler-type reaction. The separation of diastereomers and the application of the copper complexes of these ligands for cyclopropanation reactions proves the applicability of these new types of ligands.

Regioselective Chlorination of Quinoline N-Oxides and Isoquinoline N-Oxides Using PPh3/Cl3CCN

Qiao, Kai,Wan, Li,Sun, Xiaoning,Zhang, Kai,Zhu, Ning,Li, Xin,Guo, Kai

, p. 1606 - 1611 (2016/04/05)

A novel method for the regioselective C2-chlorination of heterocyclic N-oxides has been developed. PPh3/Cl3CCN were used as chlorinating reagents and the desired N-heterocyclic chlorides were obtained smoothly in satisfactory yields. The reactions proceeded in a highly efficient and selective manner across a broad range of substrates demonstrating excellent functional group tolerance. In addition, this chlorination reaction can be used for the modification of N-heterocyclic scaffolds of appealing ligands and pharmaceuticals.

A practical and mild chlorination of fused heterocyclic N-oxides

Wang, Dong,Jia, Hailing,Wang, Wuchang,Wang, Zhe

supporting information, p. 7130 - 7132 (2015/02/02)

Fused azine N-oxides were selectively chlorinated at C2 in moderate to excellent yields, employing Vilsmeier reagent as both the activating agent and the nucleophilic chloride source. Remarkable features of the method include simple operation, mild reaction conditions, a wide substrate scope, and the use of only stoichiometric amount of POCl3. The potential extension of this method to a one-pot oxidation/chlorination sequence that obviates the need for isolation of the N-oxide intermediates is also validated.

NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS

-

, (2011/12/02)

Unsaturated nitrogen heterocyclic compounds of formula (I): (I), as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES

-

Page/Page column 90-91, (2010/07/09)

Compounds of Formula I: (I) in which A, A1, R1, R7a, R7b, R8 and R10 have the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment of useful in the treat

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