422519-72-0

Basic information

• Product Name: 2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester
• CAS NO: 422519-72-0
• Molecular Formula: C13H15BrO2
• Molecular Weight: 283.165
• Mol File: 422519-72-0.mol

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester(422519-72-0)
• EPA Substance Registry System: 2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester(422519-72-0)

Safety Data

• Hazardous Substances Data: 422519-72-0(Hazardous Substances Data)

Upstream product

• 1200-07-3 3-(4-bromophenyl)acrylic acid 
• 13565-09-8 4-bromocinnamoyl chloride 
• 75-65-0 tert-butyl alcohol 
• 1663-39-4 tert-Butyl acrylate 
• 589-21-9 (4-bromophenyl)hydrazine 
• 589-87-7 1,4-bromoiodobenzene 

Downstream Products

• 1363722-12-6 tert-butyl (3R,4R)-4-fluoro-4-{2-[(S)-p-tolylsulfinyl]phenyl}-3-(4-bromophenyl)butanoate 
• 1363722-23-9 tert-butyl (3S,4R)-4-fluoro-4-{2-[(S)-p-tolylsulfinyl]phenyl}-3-(4-bromophenyl)butanoate 
• 475077-01-1 tert-butyl (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)-amino]-3-(4'-bromophenyl)propanoate 
• 1332928-70-7 tert-butyl (2S,3R,αS)-2-deuterio-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-(4'-bromophenyl)propanoate 

Relevant articles and documents

Bioactivity and structure-activity relationship of cinnamic acid esters and their derivatives as potential antifungal agents for plant protection

A series of cinnamic acid esters and their derivatives were synthesized and evaluated for antifungal activities in vitro against four plant pathogenic fungi by using the mycelium growth rate method. Structure-activity relationship was derived also. Almost all of the compounds showed some inhibition activity on each of the fungi at 0.5 mM. Eight compounds showed the higher average activity with average EC50 values of 17.4-28.6 μg/mL for the fungi than kresoxim-methyl, a commercial fungicide standard, and ten compounds were much more active than commercial fungicide standards carbendazim against P. grisea or kresoxim-methyl against both P. grisea and Valsa Mali. Compounds C1 and C2 showed the higher activity with average EC50 values of 17.4 and 18.5 μg/mL and great potential for development of new plant antifungal agents. The structure-activity relationship analysis showed that both the substitution pattern of the phenyl ring and the alkyl group in the alcohol moiety significantly influences the activity. There exists complexly comprehensive effect between the substituents on the phenyl ring and the alkyl group in the alcohol moiety on the activity. Thus, cinnamic acid esters showed great potential the development of new antifungal agents for plant protection due to high activity, natural compounds or natural compound framework, simple structure, easy preparation, low-cost and environmentally friendly.

PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF

Disclosed herein is a compound of Formula (AIII) or (III), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.

Palladium-catalyzed Heck coupling of arylhydrazines via C-NHNH2 bond activation

A novel palladium-catalyzed Heck coupling reaction of arylhydrazines with olefins is described, which affords various styrenes with high efficiency. This transformation proceeds through a C-NHNH2 bond activation under mild conditions.

Multifunctional and robust covalent organic framework-nanoparticle hybrids

Highly dispersed Pd(0) nanoparticles were successfully immobilized into a stable, crystalline and porous covalent organic framework (COF), TpPa-1, by a solution infiltration method using NABH4 as a reducing agent. High resolution and dark field TEM images confirmed the uniform loading of the Pd(0) nanoparticles into the TpPa-1 matrix without aggregation. This hybrid material exhibited excellent catalytic activity towards the Cu free Sonogashira, Heck and sequential one pot Heck-Sonogashira cross-coupling reactions under basic conditions, and with superior performance compared to commercially available Pd supported on activated charcoal (i.e., 1, 5 and 10 wt%). Additionally, the precursor Pd(ii)-doped COF also displayed competitive catalytic activity for the intramolecular oxidative biaryl synthesis under acidic conditions. Both catalysts were found to be highly stable under the reaction conditions showing negligible metal leaching, non-sintering behavior, and good recyclability. To the best of our knowledge, the organic support used in this work, TpPa-1, constitutes the first COF matrix that can hold both Pd(0) nanoparticles and Pd(ii) complex without aggregation for catalytic purposes under both highly acidic and basic conditions. This journal is the Partner Organisations 2014.

Poly(ethylene glycol) as reaction medium for mild Mizoroki-Heck reaction in a ball-mill

Phosphine-free palladium-catalyzed Mizoroki-Heck reaction was performed using ball-milling in polyethylene glycol under mild conditions. Good to excellent yields of coupling products were obtained. This activation technique also allowed the concomitant fo