4226-36-2

Usage

InChI:InChI=1/C7H8ClN.ClH/c8-4-3-7-2-1-5-9-6-7;/h1-2,5-6H,3-4H2;1H

Upstream product

• 6293-56-7 3-pyridinylethanol 
• 122374-29-2 4(4-methylsulfonylaminophenylthio) piperidine hydrochloride 
• 6419-36-9 3-pyridineacetic acid hydrochloride 
• 39998-25-9 methyl pyridine-3-acetate 

Downstream Products

• 113558-75-1 4-(4-methylsulfonylaminobenzoyl)-1-[2-(pyridin-3-yl)ethyl]piperidine 
• 131728-13-7 N-[4-Methoxymethyl-1-(2-pyridin-3-yl-ethyl)-piperidin-4-yl]-N-phenyl-propionamide 
• 131728-11-5 4-(Phenyl-propionyl-amino)-1-(2-pyridin-3-yl-ethyl)-piperidine-4-carboxylic acid methyl ester 
• 556825-56-0 3-(2-mercaptoethyl)pyridine 

Relevant academic research and scientific papers

PROCESS FOR PREPARING BISPHENOL

Provided is a process for producing a bisphenol compound stably at a high conversion and with high selectivity over a long period. A process for producing a bisphenol compound by feeding a phenol compound and a carbonyl compound continuously to a reactor packed with an acid catalyst, characterized in that the acid catalyst is a sulfonic-acid-form cation-exchange resin in which part of the sulfo groups have been modified with at least any one of 2-pyridylalkanethiol compounds and 3-pyridylalkanethiol compounds.

New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics

A series of new 1-(heterocyclyalkyl)-4-(propionanilido)-4-piperidinyl methyl esters and methylene methyl ethers have been synthesized and pharmacologically evaluated. In the mouse hot-plate test, the majority of compounds exhibited an analgesia (ED50 1 mg/kg) superior to that of morphine. These studies revealed a pharmacological accommodation for many more structurally diverse and far bulkier aromatic ring systems than the corresponding components of the arylethyl groups of the prototypic methyl ester (carfentanil, 2) and methylene methyl ether (sufentanil, 3 and alfentanil, 4) 4-propionanilido analgesics. Compound 9A (methyl 1-[2-(1H-pyrazol-1-yl)-ethyl]-4-[(1-oxopropyl) phenylamino]-4-piperidinecarboxylate), which exhibited appreciable μ-opioid receptor affinity, was a more potent and short-acting analgesic, than alfentanil with less respiratory depression in the rat. On the other hand, the phthalimides 57A and 57B, which exhibited negligible affinity for opioid receptors associated with the mediation of nociceptive transmission (i.e., μ-, κ-, and δ-subtypes), displayed analgesic efficacy in all antinociception tests. In addition, while 57B, compared to clinical opioids, showed a superior recovery of motor coordination after regaining of righting reflex from full anesthetic doses in the rat rotorod test, 57A showed significantly less depression of cardiovascular function at supraanalgesic doses in the isoflurane-anesthetized rat.

Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same

A piperidine compound has the generic formula and is useful to treat arrhythmia. STR1 in which R1 is a lower alkyl and W is: STR2 X is --S--, --SO-- or --SO2 --, R2 is hydrogen or --(CH2)n --Y, n is a