42262-96-4Relevant academic research and scientific papers
Diamine derivatives of quinone and uses thereof
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Page/Page column 12, (2010/02/10)
Diamine derivatives of quinones, and related compounds, including salts thereof, that modulate the levels of gene expression in cellular systems, such as cancer cells, are disclosed, along with methods for preparing such compounds and derivatives, as well as pharmaceutical compositions containing these compounds and derivatives as active ingredients. Methods of using these as compounds and derivatives as therapeutic agents are also described.
Reaction of 2-chloro-3-(4-N,N-dimethylaminoanilino)-1,4-naphthoquinone with cyclic amines (piperidine, morpholine, and pyrrolidine)
Mikhalina, T. V.,Rubashki, S. V.,Fokin, E. P.,Bagryanskaya, I. Yu.,Gatilov, Yu. V.
, p. 2346 - 2349 (2007/10/03)
It was shown that the reaction of 2-chloro-3-(4-N,N-dimethylaminoanilino)-1,4-naphthoquinone wwith piperidine in the absence of a solvent gives not only a product of replacement of the chlorine atom by a piperidino group, 3-(4-N,N-dimethylaminoanilino)-2-piperidino-1,4-naphthoquinone, but also 2-(4-N,N-dimethylaminoanilino)-1,4-naphthoquinone and 2-(4-N,N-dimethylaminoanilino-2-piperidino)-1,4-naphthoquinone.The latter compounds are the only reaction products formed in dimethyl sulfoxide.The reaction with morpholine occurs in a similar way, whereas that with pyrrolidine gives only a product of replacement of the chlorine atom by hydrogen. - Key words: 2-chloro-(4-N,N-dimethylaminoanilino)-1,4-naphthoquinone, cyclic amines.
