94209-18-4Relevant academic research and scientific papers
Reaction of 2-chloro-3-(4-N,N-dimethylaminoanilino)-1,4-naphthoquinone with cyclic amines (piperidine, morpholine, and pyrrolidine)
Mikhalina, T. V.,Rubashki, S. V.,Fokin, E. P.,Bagryanskaya, I. Yu.,Gatilov, Yu. V.
, p. 2346 - 2349 (1995)
It was shown that the reaction of 2-chloro-3-(4-N,N-dimethylaminoanilino)-1,4-naphthoquinone wwith piperidine in the absence of a solvent gives not only a product of replacement of the chlorine atom by a piperidino group, 3-(4-N,N-dimethylaminoanilino)-2-piperidino-1,4-naphthoquinone, but also 2-(4-N,N-dimethylaminoanilino)-1,4-naphthoquinone and 2-(4-N,N-dimethylaminoanilino-2-piperidino)-1,4-naphthoquinone.The latter compounds are the only reaction products formed in dimethyl sulfoxide.The reaction with morpholine occurs in a similar way, whereas that with pyrrolidine gives only a product of replacement of the chlorine atom by hydrogen. - Key words: 2-chloro-(4-N,N-dimethylaminoanilino)-1,4-naphthoquinone, cyclic amines.
Novel 2-amine substituted 1,4-naphthoquinone compounds and pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient
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Paragraph 0169-0173, (2018/04/21)
The present invention relates to a novel 2-amine substituted 1,4-naphthoquinone compound in which various amine groups are substituted at the 2-position of 1,4-naphthoquinone, and a pharmaceutical composition for preventing or treating cancer comprising the same. The 2-amine substituted 1,4-naphthoquinone compound of the present invention exhibits low cytotoxicity and exhibits excellent inhibitory activity against cancer cells, particularly colon cancer or ovarian cancer cells, and thus can be effectively used for prevention or treatment of cancer.COPYRIGHT KIPO 2018
Reaction of Quinones with Nitrosoarenes
Forrester, A. R.,Thomson, R. H.
, p. 1515 - 1518 (2007/10/02)
The structure of the dinitrone formed on reaction of nitrosobenzene with 1,4-benzoquinone has been confirmed by spectroscopic measurements.An electron transfer radical-anion mechanism is suggested to account for its formation. - Keywords: Addition, Nitrosobenzene, 4-Benzoquinone, Nitroxide, Trap
