42274-61-3

Basic information

• Product Name: 1-Propanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, 4-methylbenzenesulfonate, (2S)-
• Synonyms: 1-Propanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, 4-methylbenzenesulfonate, (2S)-;1-Propanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, 4-Methylbenzenes;(2S)-2-((Tetrahydro-2H-pyran-2-yl)oxy)-propyl 4-methylbenzenesulfonate;(2S)-2-[(tetrahydro-2H-pyran-2-yl)oxy]-1-Propanol4-methylbenzenesulfonate
• CAS NO: 42274-61-3
• Molecular Formula: C₁₅H₂₂O₅S
• Molecular Weight: 314.39718
• Mol File: 42274-61-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 452.354°C at 760 mmHg
• Flash Point: 227.376°C
• Appearance: /
• Density: 1.219g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Propanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, 4-methylbenzenesulfonate, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, 4-methylbenzenesulfonate, (2S)-(42274-61-3)
• EPA Substance Registry System: 1-Propanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, 4-methylbenzenesulfonate, (2S)-(42274-61-3)

Safety Data

• Hazardous Substances Data: 42274-61-3(Hazardous Substances Data)

Usage

General Description

1-Propanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, 4-methylbenzenesulfonate, (2S)-, is a chemical compound used in various pharmaceutical and industrial applications. It is an ester of 1-propanol and 4-methylbenzenesulfonic acid, and it is commonly used as a precursor in the synthesis of other organic compounds. This chemical is also known for its use as a solvent in the manufacturing of pharmaceuticals and as a reagent in organic synthesis. Its chemical structure and properties make it a versatile compound that has multiple uses in different industries.

InChI:InChI=1/C15H22O5S/c1-12-6-8-14(9-7-12)21(16,17)19-11-13(2)20-15-5-3-4-10-18-15/h6-9,13,15H,3-5,10-11H2,1-2H3/t13-,15?/m0/s1

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 3539-40-0 Ethyl (S)-(-)-2-tetrahydropyran-2-yloxypropionate 
• 110-87-2 3,4-dihydro-2H-pyran 
• 3539-39-7 (S)-(-)-2-(tetrahydropyranyloxy)propanol 
• 32464-98-5 (2S)-2-hydroxypropyl 4-methylbenzenesulfonate 
• 73208-70-5 ethyl (2S)-2-(tetrahydropyran-2-yloxy)propionate 
• 76946-21-9 (2S)-2-(tetrahydro-2H-pyran-2-yloxy)propan-1-ol 

Downstream Products

• 1097636-77-5 C₃₁H₃₇ClN₂O₃ 
• 1097206-23-9 C₃₁H₃₆Cl₂N₂O₃ 
• 1097211-02-3 C₂₉H₃₄ClN₃O₅ 
• 916811-83-1 2-allyloxy-3-[2-(tetrahydro-pyran-2-yloxy)-propoxy]-benzaldehyde 
• 83725-73-9 (S)-2-(Tetrahydro-2'-pyranoxy)-4,7-dioxa-9-nonanol 
• 1026861-04-0 C₂₂H₃₄O₆ 
• 85337-90-2 (1S,8S)-(+)-1,8-dimethyl-4,5-benzo-3,6-dioxaoctane-1,8-diol 
• 16088-62-3 (S)-Propylene oxide 
• 61217-63-8 (S,S)-(+)-bis(2-hydroxypropyl) ether 
• 143331-41-3 (2S,12S)-(-)-2,12-bis(tetrahydropyranyloxy)-7-trityl-7-aza-4,10-dioxatridecane 
• 131889-37-7 Methyl 4-<(S)-2-(tetrahydro-2-pyranoxy)propoxy>-benzoate 
• 103239-97-0 1-(benzyloxy)-4-<(S)-2-<(tetrahydro-2-pyranyl)oxy>propoxy>benzene 

Relevant articles and documents

Tubular organization with coiled ribbon from amphiphilic rigid-flexible macrocycle

We have synthesized an amphiphilic rigid-flexible macrocycle (fcoil = 0.68) consisting of hexa-p-phenylene and aliphatic polyether chain. The macrocyclic molecule in bulk state self-organizes into a 2-D body-centered rectangular structure (a = 4.3 nm and b = 6.3 nm). In aqueous solution, the macrocycle self-assembles into well-defined ribbonlike aggregates with a rod tilt relative to the ribbon normal at the initial stage. These elementary fibrils are further coiled to form a tubular structure consisting of coiled ribbons with a uniform diameter of about 20 nm and a regular pitch of 4.7 nm, as confirmed by TEM experiments. The internal diameter and the wall thickness of the nanotube are measured to be 14 and 3 nm, respectively. Copyright

SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS

Compounds of Formula (I) or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.

SYNTHESIS OF ENANTIOMERIC N-(2-PHOSPHONOMETHOXYPROPYL) DERIVATIVES OF PURINE AND PYRIMIDINE BASES. I. THE STEPWISE APPROACH

The (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases (PMP derivatives) exhibit very high activity against retroviruses.This paper describes the synthesis of enantiomeric 9-(2-phosphonomethoxypropyl)adenines (I and XXVII), 9-(2-phosphonomethoxypropyl)-2,6-diaminopurines (II and XXXI), 9-(2-phosphonomethoxypropyl)guanines (III and XXIX) and 1-(R)-(2-phosphonomethoxypropyl)cytosine (XIX) by alkylation of N-protected N-(2-hydroxypropyl) derivatives of the corresponding bases with bis(2-propyl) p-toluenesulfonyloxymethylphosphonate (X), followed by stepwise N- and O-deprotection of the intermediates.The key intermediates, N-(2-hydropxypropyl) derivatives IX and XXV, were obtained by alkylation of the appropriate heterocyclic base with (R)- or (S)-2-(2-tetrahydropyranyloxy)propyl p-toluenesulfonate (VII or XXIII) ans acid hydrolysis of the resulting N- derivatives VIII and XXII.The chiral synthons were prepared by tosylation of (R)- or (S)-2-(2-tetrahydropyranyloxy)propanol (VI or XXI) available by reduction of enantiomeric alkyl 2-O-tetrahydropyranyllactates V and XXI with sodium bis(2-methoxyethyoxy)aluminum hydride.This approach was used for the synthsis of cytosine, adenine and 2,6-diaminopurine derivatives, while compounds derived from guanine were prepared by hydrolysis of 2-amino-6-chloropurine intermediates.Cytosine derivative IXe was also synthesized by alkylation of 4-methoxy-2-pyrimidone followed by ammonolysis of the intermediate IXf.