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2-(Trifluoromethyl)-5,7-dichloro-1H-benzoimidazole is a chemical compound with the molecular formula C8H3Cl2F3N2. It is a derivative of benzoimidazole, a heterocyclic aromatic organic compound consisting of a benzene ring fused to an imidazole ring. The compound features a trifluoromethyl group (-CF3) at the 2-position, and two chlorine atoms (-Cl) at the 5 and 7 positions. This specific arrangement of functional groups endows the molecule with unique chemical and physical properties, making it potentially useful in various applications, such as pharmaceuticals, agrochemicals, or materials science. Due to its halogenated nature, it may exhibit different reactivity and stability compared to non-halogenated benzoimidazoles.

4228-88-0

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4228-88-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4228-88-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,2 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4228-88:
(6*4)+(5*2)+(4*2)+(3*8)+(2*8)+(1*8)=90
90 % 10 = 0
So 4228-88-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H3Cl2F3N2/c9-3-1-4(10)6-5(2-3)14-7(15-6)8(11,12)13/h1-2H,(H,14,15)

4228-88-0Downstream Products

4228-88-0Relevant academic research and scientific papers

TYK2 INHIBITORS AND USES THEREOF

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Paragraph 00891; 00892, (2018/05/15)

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Rapid one-pot preparation of 2-substituted benzimidazoles from 2-nitroanilines using microwave conditions

VanVliet, David S.,Gillespie, Paul,Scicinski, Jan J.

, p. 6741 - 6743 (2007/10/03)

A high yielding one-pot procedure for the generation of 2-substituted benzimidazoles directly from 2-nitroanilines by in situ reduction and cyclization using a microwave procedure is described.

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