42291-93-0Relevant academic research and scientific papers
CATALYSE HETEROGENE PAR DES SELS ET SANS SOLVANT. III. SYNTHESE DE COMPOSES CARBONYLES α,β INSATURES A PARTIR D'ETHERS D'ENOLS SILYLES
Boyer, J.,Corriu, R. J. P.,Perz, R.,Reye, C.
, p. 157 - 166 (1980)
The reactions of silyl enol ethers with carbonyl compounds are activated by heterogeneous catalysis.Caesium fluoride is the best catalyst.Unsaturated ketones are directly obtained by condensation reactions of silyl enol ethers with aldehydes and ketones. 1,4 Addition with α,β-unsaturated carbonyl compounds gives 1,5 dicarbonyl products.This method is very convenient and the compounds obtained can easily be separated.We assume that the role of the salt in these reactions is to activate the silicon atom by anionic coordination to form a pentacoordinated silicon intermediate.
ALLOSTERIC INHIBITORS OF ATYPICAL PROTEIN KINASES C
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Paragraph 0086; 0108; 0131, (2015/06/08)
The invention provides specific small molecule compounds that allosterically regulate the activity of atypical protein kinase C, their use as a medicament, and their use in the treatment and prevention of allergic, inflammatory and autoimmune disorders, cancer, hyperproliferation, sepsis, viral and protozoan infections, dementing diseases, metabolic, sclerotic and osteoporotic disorders.
