42307-43-7Relevant academic research and scientific papers
P(NMe2)3-Mediated Umpolung Alkylation and Nonylidic Olefination of α-Keto Esters
Wang, Sunewang Rixin,Radosevich, Alexander T.
, p. 3810 - 3813 (2015/08/18)
A commercial phosphorus-based reagent (P(NMe2)3) mediates umpolung alkylation of methyl aroylformates with benzylic and allylic bromides, leading to either Barbier-type addition or ylide-free olefination products upon workup. The reaction sequence is initiated by a two-electron redox addition of the tricoordinate phosphorus reagent with an α-keto ester compound (Kukhtin-Ramirez addition). A mechanistic rationale is offered for the chemoselectivity upon which the success of this nonmetal mediated C-C bond forming strategy is based.
Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A
Pieroni, Marco,Annunziato, Giannamaria,Azzali, Elisa,Dessanti, Paola,Mercurio, Ciro,Meroni, Giuseppe,Trifiró, Paolo,Vianello, Paola,Villa, Manuela,Beato, Claudia,Varasi, Mario,Costantino, Gabriele
, p. 377 - 386 (2015/03/05)
Epigenetics alterations including histone methylation and acetylation, and DNA methylation, are thought to play important roles in the onset and progression of cancer in numerous tumour cell lines. Lysinespecific demethylase 1 (LSD1 or KDM1A) is highly ex
Triethylamine-induced Reactions of Methyl 2,3-Dibromo-2,3-diarylpropanoates in Methanol
Badajoz, Mercedes A.,Montani, Rosana S.,Cabaleiro, Mercedes C.
, p. 124 - 125 (2007/10/03)
The title compounds undergo elimination with methanolic triethylamine to afford the corresponding debrominated olefins, most of them through an E2 stereoconvergent process.
