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423136-40-7

423136-40-7

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423136-40-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 423136-40-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,3,1,3 and 6 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 423136-40:
(8*4)+(7*2)+(6*3)+(5*1)+(4*3)+(3*6)+(2*4)+(1*0)=107
107 % 10 = 7
So 423136-40-7 is a valid CAS Registry Number.
InChI:InChI=1/C26H25N3O5S/c1-3-29(19-10-5-4-6-11-19)35(32,33)20-13-14-23-21(15-20)25(30)22(17-27-23)26(31)28-16-18-9-7-8-12-24(18)34-2/h4-15,17H,3,16H2,1-2H3,(H,27,30)(H,28,31)

423136-40-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-[ethyl(phenyl)sulfamoyl]-N-[(2-methoxyphenyl)methyl]-4-oxo-1H-quinoline-3-carboxamide

1.2 Other means of identification

Product number -
Other names Sulfonamide-03 (SF-03)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:423136-40-7 SDS

423136-40-7Downstream Products

423136-40-7Relevant articles and documents

Sulfamoyl-4-oxoquinoline-3-carboxamides: Novel potentiators of defective ΔF508-cystic fibrosis transmembrane conductance regulator chloride channel gating

Suen, Yat Fan,Robins, Lori,Yang, Baoxue,Verkman,Nantz, Michael H.,Kurth, Mark J.

, p. 537 - 540 (2007/10/03)

The synthesis of a small collection of sulfamoyl-4-oxoquinoline-3- carboxamides is described for use as correctors of defective gating of the ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Several compounds with submicromolar potency were obtained. N-Ethyl 6-(ethylphenylsulfamoyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (7b) was found to be the most effective sulfonamide corrector of defective ΔF508-CFTR gating.

COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF

-

Page/Page column 48-49; figure 2, (2008/06/13)

The invention provides compositions, pharmaceutical preparations and methods for increasing activity (e.g., ion transport) of the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR), e.g., DF508 CFTR, G551D-CFTR, G1349D-CFTR,

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