876303-57-0

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 103-69-5 N-ethyl-N-phenylamine 
• 211675-98-8 N-ethyl-4-nitro-N-phenylbenzenesulfonamide 
• 50497-33-1 4-amino-N-ethyl-N-phenylbenzene sulfonamide 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 423136-40-7 6-(ethylphenylsulfamoyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 2-methoxybenzylamide 
• 853139-10-3 6-(ethyl-phenyl-sulfamoyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Sulfamoyl-4-oxoquinoline-3-carboxamides: Novel potentiators of defective ΔF508-cystic fibrosis transmembrane conductance regulator chloride channel gating

The synthesis of a small collection of sulfamoyl-4-oxoquinoline-3- carboxamides is described for use as correctors of defective gating of the ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Several compounds with submicromolar potency were obtained. N-Ethyl 6-(ethylphenylsulfamoyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (7b) was found to be the most effective sulfonamide corrector of defective ΔF508-CFTR gating.