423150-36-1

Upstream product

• 2728-04-3 N,N-diethyl-ortho-toluamide 
• 89942-45-0 2-(hydroxymethyl)benzenecorbonitrile 
• 325166-90-3 3-[2-(4-methoxybenzyloxymethyl)phenyl]-2H-isoquinolin-1-one 

Relevant academic research and scientific papers

Antiviral activity of isoquinolone derivatives against influenza viruses and their cytotoxicity

Influenza viruses are one of the major causative agents for human respiratory infections. Currently, vaccines and antivirals approved for preventing and treating viral infections are available. However, limited protection efficacy and frequent emergence o

Structural modification of 3-arylisoquinolines to isoindolo[2,1-b]isoquinolinones for the development of novel topoisomerase 1 inhibitors with molecular docking study

Isoindolo[2,1-b]isoquinolinones 9a-i were designed and synthesized as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, 9d exhibited potent topoisomerase 1 inhibitory activity with cy