325166-90-3

Upstream product

• 2170-09-4 N,2-dimethylbenzamide 
• 2728-04-3 N,N-diethyl-ortho-toluamide 

Downstream Products

• 325166-93-6 3-[2-(4-methoxy-benzyloxymethyl)-phenyl]-2-methyl-2H-isoquinolin-1-one 
• 423150-36-1 C₁₆H₁₃NO₂ 
• 1202036-62-1 3-[2-(4-methoxybenzyloxymethyl)phenyl]-2-vinyl-2H-isoquinolin-1-one 
• 244128-28-7 4-bromo-2-methyl-3-(2-vinylphenyl)-1(2H)-isoquinolinone 
• 244128-27-6 2-(4-bromo-2-methyl-1-oxo-1,2-dihydro-3-isoquinolinyl)benzaldehyde 
• 946075-33-8 C₂₅H₂₂BrNO₃ 
• 946075-36-1 C₁₇H₁₄BrNO₂ 

Relevant academic research and scientific papers

Total synthesis of 8-oxypseudopalmatine and 8-oxypseudoberberine via ring-closing metathesis

Concise synthesis of 8-oxypseudopalmatine and 8-oxypseudoberberine has been achieved using ruthenium-catalyzed ring-closing metathesis (RCM) as the key step, in which the RCM substrates, 3-arylisoquinolinones, were prepared by lithiated cycloaddition reac

Structural modification of 3-arylisoquinolines to isoindolo[2,1-b]isoquinolinones for the development of novel topoisomerase 1 inhibitors with molecular docking study

Isoindolo[2,1-b]isoquinolinones 9a-i were designed and synthesized as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, 9d exhibited potent topoisomerase 1 inhibitory activity with cy

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

11-Hydroxyindeno[1,2-c]isoquinolines 12a-c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ibutoxy analog 15l displayed potent in vitro cytotoxici

Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors

An intramolecular radical cyclization reaction of 4-bromo-3-arylisoquinolines 11a-c allowed the efficient synthesis of 11-methylindenoisoquinolines 2a-c. 5-(2-Aminoethylamino)indeno[1,2-c]isoquinolin-11-one 4 was also prepared in the convenient manner. Th