423171-31-7

Upstream product

• 4707-47-5 2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester 
• 908291-87-2 4-O-(t-butoxycarbonyl)-3-methyl-6-(2-oxopropyl)-2-(trimethylsilyl)ethoxy methylbenzoate 
• 908291-88-3 8-(2-(trimethylsilyl)ethoxy)-3,7-dimethyl-1-oxo-1H-isochromen-6-yl tert-butyl carbonate 
• 908291-86-1 4-O-(t-butoxycarbonyl)-3,6-dimethyl-2-(trimethylsilyl)ethoxy methylbenzoate 
• 908292-00-2 4-O-(t-butoxycarbonyl)-2-hydroxy-3,6-dimethyl methylbenzoate 
• 908291-99-6 3-(2-(trimethylsilyl)ethoxy)-4-formyl-2-methyl-5-(2-oxopropyl)phenyl-tert-butyl carbonate 
• 122-51-0 orthoformic acid triethyl ester 
• 423171-38-4 1-(3,5-dihydroxy-4-methylphenyl)-2-propanone 

Relevant academic research and scientific papers

Total synthesis of (±)-mitorubrinic acid

(±)-Mitorubrinic acid, a member of the azaphilone family of natural products, has been constructed in 12 steps. Key aspects of the synthesis include elaboration and oxidative dearomatization of an isocoumarin intermediate to provide the azaphilone nucleus

Synthesis of 7-acetyloxy-3,7-dimethyl-7,8-dihydro-6H-isochromene-6,8-dione and its analogues

7-Alkanoyloxy-3,7-dimethyl-7,8-dihydro-6H-isochromene-6,8-diones 12-15 were synthesized in 69-16% yields from the reaction of 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde 11 with p-toluenesulfonic acid in various carboxylic acids such as acetic acid