42340-32-9

Usage

Uses

Used in Pharmaceutical Research and Development:
2-(4-METHOXYPHENYL)-1H-BENZ(de)ISO-QUINOLINE-1,3(2H)-DIONE is utilized as a key component in the discovery and development of new pharmaceuticals, given its potential pharmacological effects. It is particularly valuable for its possible applications in the treatment of a range of diseases, as researchers and scientists continue to explore its properties and efficacy.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-(4-METHOXYPHENYL)-1H-BENZ(de)ISO-QUINOLINE-1,3(2H)-DIONE serves as a structural template for the design of novel therapeutic agents. Its unique molecular features allow for the fine-tuning of its biological activity, making it a versatile building block for creating new drugs with improved pharmacokinetic and pharmacodynamic profiles.
Used in Drug Discovery:
2-(4-METHOXYPHENYL)-1H-BENZ(de)ISO-QUINOLINE-1,3(2H)-DIONE is employed in drug discovery processes to identify lead compounds with potential therapeutic applications. Its presence in screening libraries aids in the rapid evaluation of its biological activity against various targets, facilitating the advancement of promising drug candidates.
Used in Disease Treatment:
Although specific applications are still under investigation, 2-(4-METHOXYPHENYL)-1H-BENZ(de)ISO-QUINOLINE-1,3(2H)-DIONE holds promise for use in the treatment of various diseases. Its potential pharmacological effects suggest that it may play a role in managing or curing conditions that are currently challenging to treat with existing medications.

Upstream product

• 81-84-5 1,8-Naphthalic anhydride 
• 2101-87-3 p-methoxy-phenylazide 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 6424-77-7 2,9-bis(4-methoxyphenyl)anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetraone 

Relevant academic research and scientific papers

Persistent Room-Temperature Radicals from Anionic Naphthalimides: Spin Pairing and Supramolecular Chemistry

N-Substituted naphthalimides (NNIs) have been shown to exhibit highly efficient and persistent room-temperature phosphorescence from an NNI-localized triplet excited state, when the N-substitution is a sufficiently strong donor and mediates an intramolecu

Ionic liquids accelerate access to N-substituted-1,8-naphthalimides

The synthesis of N-substituted-1,8-naphthalimides is accelerated in the presence of the room temperature ionic liquid [BMIM][NO3]. Reaction times are reduced from 18 h in volatile organic compounds (VOCs) (PhCH 3, EtOH and THF) to 20 min in the ionic liquid [BMIM][NO 3]. The reaction yields are typically increased to >85% and the products are isolated by ethanol-mediated precipitation direct from the ionic liquid, requiring no further purification. Crown Copyright

Matrix screening of substituted N-aryl-1,8-naphthalimides reveals new dual fluorescent dyes and unusually bright pyridine derivatives

A 3 × 14 matrix of substituted N-aryl-1,8-naphthalimides was synthesized for the evaluation and discovery of dual fluorescence. Because of their unique photophysical properties, these dual fluorescent systems represent an exception to the widely studied T

A "green" route to perylene dyes: Direct coupling reactions of 1,8-naphthalimide and related compounds under mild conditions using a "new" base complex reagent, t-BuOK/DBN

The direct coupling reactions of 1,8-naphthalimide compounds efficiently occurred at 130 or 170 °C without the intervention of the leuco form dyes in the presence of base complex reagent, t-BuOK/1,5-diazabicyclo[4.3.0]non-5-ene (DBN), to give the corresponding perylene dyes in good yields with >95% purities. A possible mechanistic speculation for these oxidative coupling reactions is briefly discussed.

Analgesic activity of cyclic imides: 1,8-Naphthalimide and 1,4,5,8- naphthalenediimide derivatives

In early studies, we have reported the synthesis and biological activities of several cyclic imides. The present study describes the analgesic activity of 1,8-naphthalimide and 1,4,5,8-naphthalenediimide derivatives in a standard murine model of analgesia. The pharmacological results show that all compounds studied, given intraperitoneally, produced significant inhibition of acetic acid-induced abdominal constrictions. At the ID50 (μmol/kg) level, these cyclic imide derivatives were about 40-270- fold more potent in this assay than aspirin and acetaminophen, two well-known and widely used analgesics. These results extend previous studies on the analgesic activity of cyclic imides. (C) 2000 Elsevier Science S.A.

Efficient one-pot synthesis of N-substituted phthalimides/naphthalimides from azides and anhydrides by iodotrimethylsilane

N-Substituted phthalimides and naphthalimides have been obtained in good to excellent yields, employing chlorotrimethylsilane and sodium iodide (in situ generation of iodotrimethylsilane) from corresponding azides and anhydrides under mild conditions.

N-SUBSTITUTED ISONAPHTHALIMIDES. FORMATION AND REACTION WITH AMINES

N-Substituted isonaphthalimides and N-substituted naphthalimides, as considered previously, are formed in the reaction of 1,8-naphthaloyl chloride with primary amines.The reaction of N-substituted isonaphthalimides with sterically unhindered amines leads to the N,N'-substituted diamides of 1,8-naphthalenedicarboxylic acid.In the case of sterically hindered amines it results in isomerization to the N-substituted naphthalimides.The thermolysis of the N,N'-substituted diamides of 1,8-naphthalenedicarboxylic acid leads to amines and N-substituted naphthalimides.