42351-98-4

Upstream product

• 16710-11-5 4-(methylthio)-6-methyluracil 
• 22727-18-0 4-chloro-2-ethylsulfanyl-6-methyl-pyrimidine 
• 638-13-1 6-methyl-4-sulfanylidene-1,2,3,4-tetrahydropyrimidin-2-one 
• 626-48-2 6-Methyluracil 

Downstream Products

• 106949-15-9 salicylaldehyde-(6-methyl-2-oxo-1,2-dihydro-pyrimidin-4-ylhydrazone) 
• 72411-36-0 2,7-dimethyl-s-triazolo<1,5-c>pyrimidin-5(6H)-one 
• 76044-35-4 7-methyl-2-phenyl-s-triazolo<1,5-c>pyrimidin-5(6H)-one 
• 56881-36-8 7-Methyl-s-triazolo<4.3-c>pyrimidin-5(6H)-on 
• 57369-88-7 3-{[(6-methyl-2-oxo-1(3),2-dihydro-pyrimidin-4-yl)-hydrazono]-methyl}-rifamycin 
• 76044-61-6 N-acetoxy-N'-(7-methyl-2-phenyl-s-triazolo<1,5-c>pyrimidin-5-yl)formamidine 
• 76044-50-3 N,N-dimethyl-N'-(7-methyl-2-phenyl-s-triazolo<1,5-c>pyrimidin-5-yl)formamidine 
• 76044-55-8 N-hydroxy-N'-(7-methyl-2-phenyl-s-triazolo<1,5-c>pyrimidin-5-yl)formamidine 
• 76044-67-2 5-methyl-8-phenylbis-s-triazolo<1,5-a:1',5'-c>pyrimidine 
• 76069-26-6 5-chloro-7-methyl-2-phenyl-s-triazolo<1,5-c>pyrimidine 
• 108669-79-0 7-methyl-3-phenyl-6H-[1,2,4]triazolo[4,3-c]pyrimidin-5-one 

Relevant academic research and scientific papers

SUBSTITUTED TRIAZOLO BICYCLICCOMPOUNDS AS PDE2 INHIBITORS

The present invention is directed to substituted triazolo bicycliccompounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also

Cephalosporin derivatives

The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.

Bis-s-triazolopyrimidine and Some Simple Derivatives

A general synthetic route to the new tricyclic system bis-s-triazolopyrimidine, is reported.Thus the parent heterocycle (11a) is prepared from the key bicyclic intermediate, s-triazolopyrimidin-5-ylamine (7a), through the correspondi