108669-79-0Relevant academic research and scientific papers
The first reliable, general synthesis of the 5-oxo derivatives of 5,6-dihydro-1,2,4-triazolo[4,3-c]-pyrimidine and the rates of isomerization of the [4,3-c] compounds into their [1,5-c] isomers
Nagamatsu, Tomohisa,Fujita, Takayuki
, p. 631 - 636 (2007/10/03)
This paper describes a reliable synthesis of the 5-oxo derivatives (8) of 5,6-dihydro-1,2,4-triazolo[4,3-c]pyrimidine, by the reaction of 2-oxo-1,2-dihydropyrimidin-4-ylhydrazines (7) with the appropriate triethyl orthoesters in trifluoroacetic acid below 30°C or by the oxidative cyclization of their aldehyde hydrazones (10) with 70% nitric acid in trifluoroacetic acid below 40°C, and the rates of isomerization of the [4,3-c] compounds (8) into the [1,5-c] isomers (9).
