42352-55-6Relevant academic research and scientific papers
Nitrogen heterocyclic ring group substituted amide derivative and application thereof
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Paragraph 0280; 0286-0287, (2019/06/05)
The invention discloses a nitrogen heterocyclic ring group substituted amide derivative and application thereof, particularly relates to a novel nitrogen heterocyclic ring group substituted amide derivative and a drug composition comprising the compound, and further relates to methods for preparing the compound and the drug composition, and application of the compound and the drug composition to preparation of drugs for treating diseases or symptoms, particularly overactive bladder, excited and mediated by beta 3-adrenergic receptors. The compound and the drug composition can be used for activating the beta 3-adrenergic receptors.
A 2 - (2 - [...] -1 (2 H) - yl) acetic acid synthesis method
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Paragraph 0011; 0012, (2019/04/04)
The invention relates to 2 - (2 - [...] - 1 (2 H) - yl) acetic acid synthesis method. The main solves this compound did not industrial synthetic route before the technical problem. The technical scheme of the present invention: a 2 - (2 - [...] - 1 (2 H) - yl) acetic acid synthesis method, comprises the following steps: 1st step, the 2 - [...] dissolved nitrogen, nitrogen - dimethyl acetamide in, then adding potassium carbonate, finally adding 2 - bromo acetic acid tert-butyl. After the reaction is finished to obtain 2 - (2 - [...] - 1 (2 H) - yl) acetic acid tert-butyl. 2nd step, the 2 - (2 - [...] - 1 (2 H) - yl) acetic acid tert-butyl in soluble in methylene chloride, then adding hydrochloric acid/dioxane solution, after the completion of reaction, after-treatment to obtain 2 - (2 - [...] - 1 (2 H) - yl) acetic acid. The invention uses a readily available and inexpensive raw materials, avoid the complicated post-treatment process, only by the two-step reaction to obtain the target molecule, easy to enlarge.
HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS
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Page/Page column 50, (2009/10/30)
The present invention provides compounds of Formula I, pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS
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Page/Page column 40, (2009/10/17)
The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
