6270-63-9

Basic information

• Product Name: 2-HYDROXYPYRAZINE
• Synonyms: 2-HYDROXYPYRAZINE;SPECS AC-907/25004286;(1H)-pyrazin-2-one;Hydroxypyrazine;pyrazin-2-ol;1,2-Dihydropyrazine-2-one;2(1H)-Pyrazinone;Pyrazine-2(1H)-one
• CAS NO: 6270-63-9
• Molecular Formula: C₄H₄N₂O
• Molecular Weight: 96.09
• EINECS: 228-455-2
• Product Categories: Pyrazine
• Mol File: 6270-63-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 185-186 ºC
• Appearance: /
• Density: 1.28g/cm3
• Refractive Index: 1.595
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 11.69±0.20(Predicted)
• CAS DataBase Reference: 2-HYDROXYPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYPYRAZINE(6270-63-9)
• EPA Substance Registry System: 2-HYDROXYPYRAZINE(6270-63-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 6270-63-9(Hazardous Substances Data)

Usage

Chemical Properties

light yellow solid

Uses

2-Hydroxypyrazine also used in the synthesis of potential antioxidants. Is also used in the preparation of antibacterial agents as 2-substituted pyrazine derivatives.

InChI:InChI=1/C4H4N2O/c7-4-3-5-1-2-6-4/h1-3H,(H,6,7)

Upstream product

• 98197-78-5 2-acetoxypyrazine 
• 64-19-7 acetic acid 
• 762263-64-9 pyrazin-2-ylboronic acid 
• 1076-43-3 benzene-d6 
• 131543-46-9 Glyoxal 
• 1668-10-6 glycinamide hydrochloride 
• 5049-61-6 2-Aminopyrazine 
• 20737-42-2 3-oxo-3,4-dihydropyrazine-2-carboxylic acid 
• 149280-95-5 1-benzyloxy-2(1H)-pyrazinone 
• 290-37-9 1,4-pyrazine 
• 873-67-6 benzonitrile oxide 
• 65032-05-5 2-isopropoxypyrazine 
• 70090-29-8 sec-butoxy-pyrazine 
• 70090-30-1 2-tert-butoxypyrazine 

Downstream Products

• 444002-63-5 1-(4-Nitro-phenyl)-1H-pyrazin-2-one 
• 23229-25-6 2,6-dibromopyrazine 
• 56423-63-3 2-bromopyrazine 
• 14508-49-7 2-chloropyrazin 
• 2882-18-0 3-phenyl-2(1H)-pyrazinone 
• 1088-34-2 3,6-diphenylpyrazin-2(1H)-one 
• 344459-63-8 3-[4-(5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-3-fluoro-phenyl]-5-(pyrazin-2-yloxymethyl)-oxazolidin-2-one 
• 2882-18-0 2-hydroxy-3-phenylpyrazine 

Relevant articles and documents

Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents

To explore the application potential of dual prodrug strategies in the development of anti-HCV agents, a variety of sofosbuvir derivatives with modifications at the C4 or N3 position of the uracil moiety were designed and synthesized. Some compounds exhibited potent anti-HCV activities, such as 4e and 8a–8c with similar EC50 values (0.20–0.22 μM) comparative to that of sofosbuvir (EC50 = 0.18 μM) in a genotype 1b based replicon Huh-7 cell line. Moreover, 8b displayed a good human plasma stability profile, and was easily metabolized in human liver microsomes expectantly. On the other hand, aiming to discover novel anti-HCV nucleosides, pyrazin-2(1H)-one nucleosides and their phosphoramidate prodrugs were investigated. Several active compounds were discovered, such as 25e (EC50 = 7.3 μM) and S-29b (EC50 = 19.5 μM). This kind of nucleosides were interesting and would open a new avenue for the development of antiviral agents.

FACTOR XA INHIBITORS

The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

Ring-Centered Heterocyclic Cations and the Direct Heteroarylation of Aromatic and Heterocyclic Compounds

(matrix presented) The protonation of heterocyclic diazotates (attachment adjacent to a nitrogen atom) yields ring-centered heterocyclic carbocations that are highly reactive. The carbocations were found to alkylate aromatic and heterocyclic compounds, such as benzene, N-methylpyrrole, and 2-aminopyridine, in reactions that are synthetically useful. This carbocation involvement may serve as a paradigm for the cross-linking of DNA by nitrous acid and the anticancer activity of heterocyclic diazotates.