4236-13-9

Basic information

• Product Name: Benzeneacetonitrile, 4-chloro-a-(hydroxyimino)-
• CAS NO: 4236-13-9
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.593
• Mol File: 4236-13-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, 4-chloro-a-(hydroxyimino)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, 4-chloro-a-(hydroxyimino)-(4236-13-9)
• EPA Substance Registry System: Benzeneacetonitrile, 4-chloro-a-(hydroxyimino)-(4236-13-9)

Safety Data

• Hazardous Substances Data: 4236-13-9(Hazardous Substances Data)

Upstream product

• 143-33-9 sodium cyanide 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 140-53-4 p-chlorobenzyl cyanide 
• 104-88-1 4-chlorobenzaldehyde 
• 3848-36-0 4-chlorobenzaldoxime 
• 10349-08-3 p-Chlorphenyl-furazan 
• 7732-18-5 water 

Downstream Products

• 59577-37-6 2-tert.-Butoxycarbonyloxyimino-2-(4-chlor-phenyl)-acetonitril 
• 21741-98-0 3-amino-4-(p-chlorophenyl)-1,2,5-oxadiazole 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 13014-48-7 4-chlorobenzoyl cyanide 

Relevant articles and documents

Cu-Mediated Stereoselective [4+2] Annulation between N-Hydroxybenzimidoyl Cyanide and Norbornene

A Cu-mediated stereoselective [4+2] annulation between N-hydroxybenzimidoyl cyanides and norbornene (NBE) has been developed for the synthesis of 4H-1,2-oxazin-4-ones. The reaction proceeds through sequentially forming C-O/C-C bonds. The advantage of this reaction includes high stereoselectivity, excellent yields, as well as simple and mild reaction conditions. A total of 26 examples are presented along with some control experiments.

A convenient synthesis of α-hydroxyiminoacetonitriles from aldoximes

Aromatic α-hydroxyiminoacetonitriles can be conveniently prepared by a facile one-pot procedure in high yields involving chlorination of the corresponding aldoximes with tert-butyl hypochlorite followed by reaction with alkali cyanide.