42367-61-3Relevant academic research and scientific papers
Chiral lewis base catalyzed highly enantioselective reduction of N-alkyl β-enamino esters with trichlorosilane and water
Wu, Xinjun,Li, Yang,Wang, Chao,Zhou, Li,Lu, Xiaoxia,Sun, Jian
supporting information; experimental part, p. 2846 - 2848 (2011/04/24)
First, test the water! In the presence of a chiral Lewis base catalyst 2, the supposedly moisture-unfriendly reduction system with trichlorosilane was found to be highly efficient and enantioselective when using water as an additive. For the first time, this method enables the reduction of a broad range of N-alkyl β-enamino esters 1 to give N-alkyl β-amino esters 3 in good to high yields and with excellent enantioselectivities (see scheme).
