138116-34-4

Basic information

• Product Name: (4-AMINO-PYRIDIN-3-YL)-METHANOL
• Synonyms: RARECHEM AL BD 1386;4-AMINO-3-HYDROXYMETHYLPYRIDINE;4-AMINO-3-PYRIDINE METHANOL;(4-AMINO-PYRIDIN-3-YL)-METHANOL;4-AMINOPYRIDINE-3-METHANOL;3-Pyridinemethanol,4-amino-(9CI);3-AMINO-4-PYRIDINE METHANOL;4-Aminopyridine-3-methanol ,97%
• CAS NO: 138116-34-4
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• EINECS: 207-987-9
• Product Categories: PYRIDINE;pharmacetical;Pyridine series;Hydroxymethyl's;Pyridines
• Mol File: 138116-34-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 167-169℃
• Boiling Point: 367.19 °C at 760 mmHg
• Flash Point: 175.871 °C
• Appearance: /
• Density: 1.257 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 13.54±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• Sensitive: Air Sensitive
• Stability: Air Sensitive
• CAS DataBase Reference: (4-AMINO-PYRIDIN-3-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-AMINO-PYRIDIN-3-YL)-METHANOL(138116-34-4)
• EPA Substance Registry System: (4-AMINO-PYRIDIN-3-YL)-METHANOL(138116-34-4)

Safety Data

• Hazard Codes: Xi,T+
• Statements: 28-36/37/38
• Safety Statements: 26-36/37/39-45-37
• RIDADR: UN 2811 6.1 / PGII
• WGK Germany: 3
• RTECS: US1750000
• HazardClass: IRRITANT
• Hazardous Substances Data: 138116-34-4(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow powder

Uses

4-Amino-3-pyridinemethanol is used as an organic chemical synthesis intermediate.

InChI:InChI=1/C6H8N2O/c7-6-1-2-8-3-5(6)4-9/h1-3,9H,4H2,(H2,7,8)

Upstream product

• 42373-30-8 4-aminonicotinaldehyde 
• 86847-71-4 N-(3-formylpyridin-4-yl)-2,2-dimethylpropanamide 
• 70298-89-4 4-N-pivaloylaminopyridine 
• 504-24-5 4-aminopyridine 
• 7418-65-7 4-aminonicotinic acid 
• 1078-05-3 4-nitro-3-carboxypyridine 1-oxide 
• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 1003-73-2 3-picoline-N-oxide 
• 16135-36-7 methyl 4-aminonicotinate 

Downstream Products

• 1026039-69-9 3-chloromethyl-pyridin-4-ylamine hydrochloride 
• 1421473-35-9 3-((tert-butyldimethylsilyloxy)methyl)pyridin-4-amine 
• 1421473-36-0 phenyl 3-((tert-butyldimethylsilyloxy)methyl)pyridin-4-ylcarbamate 
• 1421473-37-1 1-(3-((tert-butyldimethylsilyloxy)methyl)pyridin-4-yl)-3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)urea 
• 1421473-31-5 1-(3-(hydroxymethyl)pyridin-4-yl)-3-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)urea 
• 407623-72-7 tert-butyl N-[3-(hydroxymethyl)pyridin-4-yl]carbamate 
• 42373-30-8 4-aminonicotinaldehyde 
• 1330531-71-9 {4-[2-(2-fluoro-5-trifluoromethyl-phenyl)-[1,8]naphthyridin-4-ylamino]-pyridin-3-yl}-methanol 
• 177592-15-3 4-hydroxy-3-hydroxymethylpyridine 

Relevant articles and documents

SUBSTITUTED HETEROCYCLIC AZA DERIVATIVES

The invention relates to heterocyclic aza derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

Tumor cells extensively utilize the pentose phosphate pathway for the synthesis of ribose. Transketolase is a key enzyme in this pathway and has been suggested as a target for inhibition in the treatment of cancer. In a pharmacodynamic study, nude mice with xenografted HCT-116 tumors were dosed with 1 ('N3′-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an analog of thiamine, the co-factor of transketolase. Transketolase activity was almost completely suppressed in blood, spleen, and tumor cells, but there was little effect on the activity of the other thiamine-utilizing enzymes α-ketoglutarate dehydrogenase or glucose-6-phosphate dehydrogenase. Synthesis and SAR of transketolase inhibitors is described.