423737-44-4Relevant academic research and scientific papers
2-oxo-1,2,3,4-tetrahydropyrimidines ethyl esters as potent β-glucuronidase inhibitors: One-pot synthesis, in vitro and in silico studies
Iqbal, Sarosh,Shaikh, Nimra N.,Khan, Khalid M.,Naz, Sehrish,Ul-Haq, Zaheer,Perveen, Shahnaz,Choudhary, Muhammad I.
, p. 818 - 830 (2018/11/30)
Background: Glucuronidation is essential for the metabolism and excretion of toxic substances. β-Glucuronidase enzyme slows down the process of glucuronidation, and thus plays an important role in the on-set of colorectal carcinoma, and many other disease
Xanthine oxidase inhibitory and molecular docking studies on pyrimidones
Zafar, Humaira,Iqbal, Sarosh,Javaid, Sumaira,Khan, Khalid M.,Choudhary, Muhammad I.
, p. 524 - 535 (2018/07/25)
Background: Xanthine oxidase is an important enzyme which catalyzes the production of uric acid and superoxide anion from xanthine. The over-production of these products leads to different disease conditions. For instance, uric acid is responsible for hyp
A microwave-assisted, copper-catalyzed three-component synthesis of dihydropyrimidinones under mild conditions
Pasunooti, Kalyan Kumar,Chai, Hua,Jensen, Chantel Nixon,Gorityala, Bala Kishan,Wang, Siming,Liu, Xue-Wei
supporting information; experimental part, p. 80 - 84 (2011/02/25)
The synthesis of dihydropyrimidinones via a clean multi-component Biginelli reaction under microwave irradiation is reported. The copper-catalyzed process proved to be simple, efficient, economical, and environmentally friendly.
P-Sulfonic acid calixarenes as efficient and reusable organocatalysts for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/-thiones
Da Silva, Daniel L.,Fernandes, Sergio A.,Sabino, Ad?o A.,De Fá, ?ngelo
experimental part, p. 6328 - 6330 (2011/12/22)
A new and efficient methodology is proposed for obtaining 3,4-dihydropyrimidin-2(1H)-ones/-thiones through Biginelli reactions. It is based on the use of less than the stoichiometric amount ofp-sulfonic acid calixarenes as organocatalysts. A number of aro
Microwave assisted synthesis of some novel pyrimidinones/thiones
Rai, Satheesha N.,Kalluraya, Balakrishna,Lingappa,Shenoy, Shalini
experimental part, p. 1431 - 1434 (2010/03/03)
A novel scries of 1-substituted-4-aryl-5-ethoxycarbonyl-6-mcthylpyrimidine- 2-ones/thiones are prepared in the one pot condensation of appropriate aldehyde, ethylacetoacetate and substituted urea in ethanol medium under microwave irradiation. The new compounds are well characterized by IR,1H NMR, mass spectra, C.H,N-analysis and in a typical example the structure was further confirmed by X-ray crystallographic data.
Solvent-free approach to 3,4-dihydropyrimidin-2(1H)-(thio)ones: Biginelli reaction catalyzed by a Wells-Dawson reusable heteropolyacid
Romanelli, Gustavo P.,Sathicq, Angel G.,Autino, Juan C.,Baronetti, Graciela,Thomas, Horacio J.
, p. 3907 - 3916 (2008/03/13)
The Biginelli reaction is performed in an efficient, simple, solvent-free procedure, using a small amount of H6P2W18O62 · 24H2O, a reusable heteropolyacid catalyst with Wells-Dawson structure. Both aromatic and aliphatic aldehydes, and different β-dicarbo
