423755-05-9

Upstream product

• 25784-91-2 2-chloro-5-nitrobenzoylchloride 
• 39513-19-4 2-amino-4-methyl-N-methylaminobenzene 
• 446-11-7 4-fluoro-3-nitrotoluene 
• 4600-08-2 4,N-dimethyl-2-nitroaniline 
• 690231-89-1 2-chloro-N-(5-methyl-2-methylamino-phenyl)-5-nitro-benzamide 

Downstream Products

• 423755-04-8 4-chloro-3-(1,5-dimethyl-1H-benzoimidazol-2-yl)-phenylamine 

Relevant academic research and scientific papers

Synthesis and SAR of 2-arylbenzoxazoles, benzothiazoles and benzimidazoles as inhibitors of lysophosphatidic acid acyltransferase-β

2-Arylbenzoxazoles, benzothiazoles and benzimidazoles were identified as new classes of potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-β (LPAAT-β). Effects of selected inhibitors on proliferation of tumor cells in vitro were investigated.

Benzoxazole LPAAT-B inhibitors and uses thereof

The invention relates to benzoxazoles and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using said benzoxazoles. The invention also relates to methods for screening for LPAAT-β activity.