42381-59-9

Upstream product

• 67-56-1 methanol 
• 115982-28-0 2-amino-3-(3,4-dimethoxyphenyl)propanoic acid hydrochloride 

Downstream Products

• 1208262-70-7 2-(3,4-dimethoxyphenyl)-7-methoxy-4-{(E)-2-[1-(methoxycarbonyl)-2-(3,4-dimethoxyphenyl)-ethylcarbamoyl]-vinyl}-2,3-dihydro-benzofuran-3-carboxylic acid 1-(methoxycarbonyl)-[2-(3,4-dimethoxyphenyl)-ethyl]-amide 
• 1208387-48-7 2-(3,4-dimethoxyphenyl)-7-methoxy-5-{(E)-2-[1-(methoxycarbonyl)-2-(3,4-dimethoxyphenyl)-ethylcarbamoyl]-vinyl}-2,3-dihydro-benzofuran-3-carboxylic acid 1-(methoxycarbonyl)-[2-(3,4-dimethoxyphenyl)-ethyl]-amide 

Relevant academic research and scientific papers

Derivatives of 8-epiblechnic Acid and their Effects on Down-Regulation of Endothelin (ETA) receptor mRNA

The present application discloses derivatives of 8-epiblechnic acid and use thereof in treating a disease related to endothelin receptor A or endothelin-1 (ET-1) over-expression, such as hypertension, cancer, atherosclerosis, and myocardial infarction.

Oleanolic acid and its derivatives: New inhibitor of protein tyrosine phosphatase 1B with cellular activities

Protein tyrosine phosphatase 1B is a key factor in the negative regulation of insulin pathway and a promising target for treatment of diabetes and obesity. Herein, a series of competitive inhibitors were optimized from oleanolic acid, a natural triterpenoid identified against PTP1B by screening libraries of traditional Chinese medicinal herbs. Modifying at 3 and 28 positions, we obtained compound 13 with a Ki of 130 nM, which exhibited good selectivity between other phosphatases involved in insulin pathway except T-cell protein tyrosine phosphatase. Further evaluation in cell models illustrated that the derivatives enhanced insulin receptor phosphorylation in CHO/hIR cells and also stimulated glucose uptake in L6 myotubes with or addition of without insulin.