42385-89-7Relevant academic research and scientific papers
Synthesis, crystal structure, and biological evaluation of a series of phloretin derivatives
Wang, Li,Li, Zheng-Wei,Zhang, Wei,Xu, Rui,Gao, Fei,Liu, Yang-Feng,Li, Ya-Jun
, p. 16447 - 16457 (2014/12/12)
A one-step synthesis of phloretin derivatives 2-11 from phloretin in good to excellent yields is reported. Their structures were characterized by 1H-NMR, 13C-NMR and MS, and the structures of 8 and 11 were determined by X-ray diffrac
Antileishmanial activities of dihydrochalcones from piper elongatum and synthetic related compounds. Structural requirements for activity
Hermoso, Alicia,Jimenez, Ignacio A.,Mamani, Zulma A.,Bazzocchi, Isabel L.,Pinero, Jose E.,Ravelo, Angel G.,Valladares, Basilio
, p. 3975 - 3980 (2007/10/03)
Two dihydrochalcones (1 and 2) were isolated from Piper elongatum Vahl by activity-guided fractionation against extracellular promastigotes of Leishmania braziliensis in vitro. Their structures were elucidated by spectral analysis, including homonuclear and heteronuclear correlation NMR experiments. Derivatives 3-7 and 20 synthetic related compounds (8-27) were also assayed to establish the structural requirements for antileishmanial activity. Compounds 1-11 that proved to be more active that ketoconazol, used as positive control, were further assayed against promastigotes of Leishmania tropica and Leishmania infantum. Compounds 7 and 11, with a C6-C3-C6 system, proved to be the most promising compounds, with IC50 values of 2.98 and 3.65 μg/mL, respectively, and exhibited no toxic effect on macrophages (around 90% viability). Correlation between the molecular structures and antileishmanial activity is discussed in detail.
