42389-59-3

Basic information

• Product Name: 4-AMINO-1-(1-PROPYL)-PIPERIDINE
• Synonyms: AKOS B016067;1-PROPYLPIPERIDIN-4-AMINE;ART-CHEM-BB B016067;CHEMBRDG-BB 4004106;4-AMINO-1-(1-PROPYL)-PIPERIDINE >98%;1-propylpiperidin-4-amine(SALTDATA: FREE);4-AMino-1-propylpiperidine di, HCl;(1-propyl-4-piperidyl)amine
• CAS NO: 42389-59-3
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24
• Product Categories: Piperidine
• Mol File: 42389-59-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 86°C/22mm
• Flash Point: 63.2 °C
• Appearance: /
• Density: 0.893 g/cm³
• Vapor Pressure: 0.805mmHg at 25°C
• Refractive Index: 1.466
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.52±0.20(Predicted)
• CAS DataBase Reference: 4-AMINO-1-(1-PROPYL)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-1-(1-PROPYL)-PIPERIDINE(42389-59-3)
• EPA Substance Registry System: 4-AMINO-1-(1-PROPYL)-PIPERIDINE(42389-59-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 42389-59-3(Hazardous Substances Data)

Usage

General Description

4-AMINO-1-(1-PROPYL)-PIPERIDINE is an organic compound with the molecular formula C10H22N2. It is a derivative of piperidine and contains an amino group at the 4 position and a propyl group at the 1 position. 4-AMINO-1-(1-PROPYL)-PIPERIDINE has potential pharmaceutical applications and is often used as an intermediate in the synthesis of various drugs and chemical compounds. It has been studied for its potential use in the treatment of central nervous system disorders and as a building block in the production of pharmaceuticals. 4-AMINO-1-(1-PROPYL)-PIPERIDINE may also have other industrial applications due to its unique chemical properties.

InChI:InChI=1/C8H18N2/c1-2-5-10-6-3-8(9)4-7-10/h8H,2-7,9H2,1H3

Upstream product

• 182223-54-7 piperidin-4-ylcarbamic acid benzyl ester 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 220394-97-8 4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine 

Downstream Products

• 1266620-15-8 C₁₆H₂₁ClFN₃O₂ 

Relevant articles and documents

Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in?vivo anti-tumor activity

Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1?cells (PF50?=?7.10, PF50?=?4.17). In?vivo tumor growth inhibition was investigated using compound 10a in combination with TMZ, and it was demonstrated that compound 10a could strongly potentiate the cytotoxicity of TMZ in MX-1 xenograft tumor model. Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.