42389-59-3 Usage
Uses
Used in Pharmaceutical Industry:
4-AMINO-1-(1-PROPYL)-PIPERIDINE is used as an intermediate in the synthesis of various drugs and chemical compounds, playing a crucial role in the development of new pharmaceuticals.
Used in Central Nervous System Disorders Treatment:
4-AMINO-1-(1-PROPYL)-PIPERIDINE is utilized in research for its potential therapeutic effects on central nervous system disorders, indicating its value in medicinal chemistry for neurological applications.
Used in Chemical Compounds Synthesis:
As a building block, 4-AMINO-1-(1-PROPYL)-PIPERIDINE is employed in the production of pharmaceuticals, underlining its importance in the creation of complex molecular structures for medicinal purposes.
Used in Industrial Applications:
Due to its unique chemical properties, 4-AMINO-1-(1-PROPYL)-PIPERIDINE may also find use in various industrial sectors, although specific applications would depend on the industry's requirements and the compound's adaptability in those contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 42389-59-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,3,8 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 42389-59:
(7*4)+(6*2)+(5*3)+(4*8)+(3*9)+(2*5)+(1*9)=133
133 % 10 = 3
So 42389-59-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H18N2/c1-2-5-10-6-3-8(9)4-7-10/h8H,2-7,9H2,1H3
42389-59-3Relevant academic research and scientific papers
Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in?vivo anti-tumor activity
Zhou, Jie,Ji, Ming,Zhu, Zhixiang,Cao, Ran,Chen, Xiaoguang,Xu, Bailing
, p. 26 - 41 (2017/03/23)
Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1?cells (PF50?=?7.10, PF50?=?4.17). In?vivo tumor growth inhibition was investigated using compound 10a in combination with TMZ, and it was demonstrated that compound 10a could strongly potentiate the cytotoxicity of TMZ in MX-1 xenograft tumor model. Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.
