220394-97-8

Basic information

• Product Name: 1-BOC-4-CBZ-AMINO-PIPERIDINE
• Synonyms: 1-BOC-4-CBZ-AMINO-PIPERIDINE;4-BENZYLOXYCARBONYLAMINO-N-BOC-PIPERIDINE;Benzyl 1-(tert-butoxycarbonyl)piperidin-4-ylcarbamate;4-Benzyloxycarbonylamino-N-Boc-piperdine;tert-butyl 4-(((benzyloxy)carbonyl)amino)piperidine-1-carboxylate;tert-butyl 4-(phenylmethoxycarbonylamino)piperidine-1-carboxylate
• CAS NO: 220394-97-8
• Molecular Formula: C₁₈H₂₆N₂O₄
• Molecular Weight: 334.41
• Mol File: 220394-97-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 88 °C
• Boiling Point: 471.582 °C at 760 mmHg
• Flash Point: 239.004 °C
• Appearance: /
• Density: 1.156 g/cm³
• Vapor Pressure: 4.6E-09mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: 2-8°C
• PKA: 12.10±0.20(Predicted)
• CAS DataBase Reference: 1-BOC-4-CBZ-AMINO-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-CBZ-AMINO-PIPERIDINE(220394-97-8)
• EPA Substance Registry System: 1-BOC-4-CBZ-AMINO-PIPERIDINE(220394-97-8)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 220394-97-8(Hazardous Substances Data)

Usage

General Description

1-BOC-4-CBZ-AMINO-PIPERIDINE, also known as tert-butoxycarbonyl-4-benzyloxycarbonyl-amino-piperidine, is a chemical compound with the molecular formula C16H24N2O3. It is a derivative of piperidine, a six-membered heterocyclic compound commonly used in organic synthesis. 1-BOC-4-CBZ-AMINO-PIPERIDINE is often utilized as a key intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. 1-BOC-4-CBZ-AMINO-PIPERIDINE is known for its versatile and important role in the development of various biologically active molecules and is commonly used as a building block for the synthesis of a wide range of compounds. It is a white to off-white solid that is sensitive to air and moisture, and should be stored and handled under inert atmosphere.

InChI:InChI=1/C18H26N2O4/c1-18(2,3)24-17(22)20-11-9-15(10-12-20)19-16(21)23-13-14-7-5-4-6-8-14/h4-8,15H,9-13H2,1-3H3,(H,19,21)

Upstream product

• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 501-53-1 benzyl chloroformate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 100-51-6 benzyl alcohol 
• 91419-48-6 4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 180695-80-1 tert-butyl 4-azidopiperidine-1-carboxylate 
• 180695-79-8 tert-butyl 4-bromo-1-piperidinecarboxylate 
• 90633-18-4 4-bromo-1H-piperidine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 182223-54-7 piperidin-4-ylcarbamic acid benzyl ester 
• 1306723-06-7 [1-(4-aminobenzenesulfonyl)piperidin-4-yl]carbamic acid benzyl ester 
• 1306723-05-6 [1-(4-nitrobenzenesulfonyl)piperidin-4-yl]carbamic acid benzyl ester 
• 1306720-02-4 [1-(4-acryloylaminobenzenesulfonyl)piperidin-4-yl]carbamic acid benzyl ester 
• 1427058-31-8 2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid 
• 1427309-25-8 tert-butyl 2-[(3S,4R)-1-benzyl-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetate 
• 1427309-26-9 tert-butyl 2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(2-fluoropentyl)piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetate 
• 132740-50-2 1-cyclopentyl-4-piperidinylamine 
• 1014695-10-3 1-(2,2-dimethylpropyl)piperidin-4-amine 
• 127285-08-9 4-amino-1-isopropylpiperidine 
• 42389-59-3 4-amino-1-propylpiperidine 
• 497177-66-9 1-(4-aminopiperidin-1-yl)-2,2,2-trifluoroethanone 
• 50534-45-7 4-amino-N-ethylpiperidine 
• 959237-16-2 tert-butyl 4-(4-amino-1-piperidyl)piperidine-1-carboxylate 

Relevant articles and documents

COMPOUND WITH ANTICANCER ACTIVITY

A compound having anticancer activity, or a pharmaceutically acceptable salt thereof is provided. Used is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: (wherein, L1 and L2 are the same or different and each represents a group represented by one formula selected from the group consisting of formulas (A) to (F), and S represents a group represented by one formula selected from the group consisting of formulas (S1) to (S18)).

Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in?vivo anti-tumor activity

Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1?cells (PF50?=?7.10, PF50?=?4.17). In?vivo tumor growth inhibition was investigated using compound 10a in combination with TMZ, and it was demonstrated that compound 10a could strongly potentiate the cytotoxicity of TMZ in MX-1 xenograft tumor model. Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.

AMIDINE COMPOUND AND BACTERICIDAL AGENT

PROBLEM TO BE SOLVED: To provide a novel amidine compound excellent in bactericidal property and safety and capable of being industrially advantageously synthesized and a bactericidal agent or plant disease control agent containing the amidine compound as an active ingredient. SOLUTION: There is provided a compound represented by the formula [I] or a salt hereof. [I], where Y is an unsubstituted/substituted bivalent cyclic amine residue, X and Z are each independently an unsubstituted/substituted alkylene group or the like, W is a singe bond or -N(R5)-, R5 is H, an unsubstituted/substituted heterocycle group or the like, R1 to R3 are each independently H, an unsubstituted/substituted hydrocarbon group or the like, A is an aryl group or a heteroaryl group substituted by carboxy amidine. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT