42404-41-1

Basic information

• Product Name: (3-amino-4-hydroxy-phenyl)-phenyl-methanone
• Synonyms: (3-amino-4-hydroxy-phenyl)-phenyl-methanone
• CAS NO: 42404-41-1
• Molecular Weight: 213.236
• Mol File: 42404-41-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (3-amino-4-hydroxy-phenyl)-phenyl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3-amino-4-hydroxy-phenyl)-phenyl-methanone(42404-41-1)
• EPA Substance Registry System: (3-amino-4-hydroxy-phenyl)-phenyl-methanone(42404-41-1)

Safety Data

• Hazardous Substances Data: 42404-41-1(Hazardous Substances Data)

Upstream product

• 1137-42-4 4-Hydroxybenzophenone 
• 98-88-4 benzoyl chloride 
• 614-80-2 2-(acetylamino)phenol 
• 5464-98-2 (4-hydroxy-3-nitrophenyl)(phenyl)methanone 

Downstream Products

• 132709-79-6 5-benzoyl-3H-1,3-benzoxazol-2-one 
• 114997-11-4 3-[N-(5-Benzoyl-benzooxazol-2-yl)-hydrazino]-propionitrile; hydrochloride 
• 82593-17-7 (2-phenyl-5-benzoxazolyl)phenylmethanone 
• 168979-99-5 4-acetamidophenyl N-(5-benzoyl-2-hydroxyphenyl)carbamate 
• 82593-18-8 3-benzoylamino-4-hydroxybenzophenone 

Relevant articles and documents

Benzophenone based fluorophore for selective detection of Sn2?+ ion: Experimental and theoretical study

Synthesis of novel benzophenone-based chemosensor is presented for the selective sensing of Sn2?+ ion. Screening of competitive metal ions was performed by competitive experiments. The specific cation recognition ability of chemosensor towards

Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies

Ceramides are lipid-derived intracellular messengers involved in the control of senescence, inflammation, and apoptosis. The cysteine amidase, acid ceramidase (AC), hydrolyzes these substances into sphingosine and fatty acid and, by doing so, regulates their signaling activity. AC inhibitors may be useful in the treatment of pathological conditions, such as cancer, in which ceramide levels are abnormally reduced. Here, we present a systematic SAR investigation of the benzoxazolone carboxamides, a recently described class of AC inhibitors that display high potency and systemic activity in mice. We examined a diverse series of substitutions on both benzoxazolone ring and carboxamide side chain. Several modifications enhanced potency and stability, and one key compound with a balanced activity-stability profile (14) was found to inhibit AC activity in mouse lungs and cerebral cortex after systemic administration. The results expand our arsenal of AC inhibitors, thereby facilitating the use of these compounds as pharmacological tools and their potential development as drug leads.

INTERMOLECULAR CHARACTER OF THE REARRANGEMENT OF AMIDES IN POLYPHOSPHORIC ACID

When N-benzoyl-o-aminophenol is heated in polyphosphoric acid, both 2-phenylbenzoxazole and 2-phenyl-5-benzoylbenzoxazole are formed, and this shows that the rearrangement of the amides has an intermolecular mechanism.The same mixture is obtained when O,N-dibenzoyl-o-aminophenol is heated under these conditions.The structure of 2-phenyl-5-benzoylbenzoxazole was proved by an alternative synthesis both from p-hydroxybenzophenone through 3-nitro- and 3-benzoylamino-4-hydroxybenzophenone and from 2-phenylbenzoxazole by heating with benzoyl chloride in the presence of zinc oxide.When heated with polyphosphoric acid, benzanilide rearranges to 4-aminobenzophenone; bis(4-benzoylaminophenyl) ether does not undergo rearrangement under these conditions.