42406-36-0Relevant academic research and scientific papers
Highly efficient stereoconservative amidation and deamidation of α-amino acids
Shendage, Deepak M.,Froehlich, Roland,Haufe, Guenter
, p. 3675 - 3678 (2007/10/03)
(Chemical Equation Presented) An overall stereoconservative protection and deprotection method of amino and carboxyl groups is presented. N-Phthaloyl N-alkyl secondary amides of α-amino acids can be generated from corresponding N-phthaloyl amino acids by coupling reaction of N-alkylamines using mixed anhydride method. These secondary amides can be transformed by thermal rearrangement of intermediate nitrosoamides to O-alkyl esters with retention of configuration and excellent yields.
Dynamic kinetic resolution utilizing 2-oxoimidazolidine-4-carboxylate as a chiral auxiliary: Stereoselective synthesis of α-amino acids by Gabriel reaction
Kubo, Akira,Kubota, Hitoshi,Takahashi, Masami,Nunami, Ken-Ichi
, p. 4957 - 4960 (2007/10/03)
A Highly stereoselective Gabriel reaction via dynamic kinetic resolution utilizing 2-oxoimidazolidine-4-carboxylate as a chiral auxiliary was exploited. The reaction of tert-butyl (4S)-1-methyl-3-(2-bromopropionyl)-2- oxoimidazolidine-4-carboxylate (2a) w
